Three series of cultured Wistar rat heart cells (10 treated and 10 controls x 3) were examined with a laser contraction-meter in a special chamber for anoxia to determine whether cytidine diphosphate choline (CDPC), a membrane phospholipid precursor, can protect against total oxygen deprivation. Heart rate and force of contraction (inotropism) were monitored during a 40-minute period of hypoxia. CDPC in a concentration of 142 micrograms/ml-1 was added to the culture medium only during the anoxia period in series I, during the 3 days of culture in series II, and during the 3 days of culture and the 40-minute hypoxia period in series III. In series I, inotropism decreased by 21% versus 55% in control group (P less than 0.05). In series II, inotropism decreased by 25% versus 43% in control group (P less than 0.05). In series III, inotropism decreased by 22% versus 44% in control group (P less than 0.05). Compared with control cells, cells treated with CDPC during anoxia maintained a significantly greater inotropic state. The effect is greatest if the cells are weak, as in series I. CDPC may be a useful component of the cardioplegic mixture during cardiopulmonary bypass and in the treatment of myocardial ischemia.
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Metabolites
January 2025
Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
When measuring real-time in vivo muscle fatigue with electromyography (), data collection can be compromised by premature sensor removal or environmental noise; therefore, the objective of this study was to develop a postmortem in vivo methodology to induce muscle fatigue and measure it using EMG. Barrows ( = 20) were stratified by weight and randomly allocated into one of two treatments. The treatments consisted of barrows being subjected to a hog electric stunner super-contraction cycle () or not () postmortem.
View Article and Find Full Text PDFCrit Care Explor
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Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
Objectives: The COVID-19 pandemic gave rise to uncertainty concerning potential sequelae related to a severe acute respiratory syndrome coronavirus 2 infection. This landscape is currently unfolding with studies reporting sequelae on various domains (physical, cognitive, and psychosocial), although most studies focus on adults or only one domain. We sought to investigate concurrent sequelae on multiple domains 1 year after PICU admission for Multisystem Inflammatory Syndrome in Children (MIS-C).
View Article and Find Full Text PDFFront Physiol
January 2025
Liberal Arts Department, American University of the Middle East, Egaila, Kuwait.
Introduction: The aim of the present study was to investigate the effects of eccentric phase tempo in squats on hypertrophy, strength, and contractile properties of the quadriceps femoris (QF) muscle.
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Am J Case Rep
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Department of Anesthesiology and Intensive Care, Legionowo Hospital, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
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View Article and Find Full Text PDFJ Funct Morphol Kinesiol
January 2025
Faculty of Sport and Physical Education, University of Belgrade, 11000 Belgrade, Serbia.
Foam rolling is widespread and deeply rooted in exercise practice. The optimal duration and role of this treatment still lack scientific consensus. A relatively novel foam rolling treatment that combines vibration during application targets different muscle characteristics that are not well understood.
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