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Structural Elucidation and In Silico-Aided Toxicity Prediction of Forced Degradation Products of Ginsenoside Re Using Ultra-High-Performance Liquid Chromatography Equipped with a Diode Array Detector and Charged Aerosol Detector (UHPLC-DAD-CAD) and Liquid Chromatography Coupled to a High-Resolution Mass Detector (LC-HRMS).
Int J Mol Sci
December 2024
National Institutes for Food and Drug Control, Beijing 102629, China.
Ginsenoside Re was the major bioactive component found rich in C. A. Meyer, which exerted excellent cardiovascular protection, anti-inflammatory, and anti-oxidation effects.
View Article and Find Full Text PDFMandibular Reconstruction with Osseous Free Flap and Immediate Prosthetic Rehabilitation (Jaw-in-a-Day): In-House Manufactured Innovative Modular Stackable Guide System.
Bioengineering (Basel)
December 2024
Department of Oral and Craniomaxillofacial Surgery, Ghent University Hospital, 9000 Ghent, Belgium.
Head and neck reconstruction following ablative surgery results in alterations to maxillofacial anatomy and function. These postoperative changes complicate dental rehabilitation. An innovative modular, stackable guide system for immediate dental rehabilitation during mandibular reconstruction is presented.
View Article and Find Full Text PDFTrueness and Internal Fit of 3D Printed Provisional Veneers: An In Vitro Comparative Study.
Bioengineering (Basel)
November 2024
Department of Prosthodontics, University of Medicine and Pharmacy "Victor Babes", B-dul Revolutiei 1989, No. 9, 300580 Timisoara, Romania.
Dentistry is steadily evolving along the digital pathway at a constant and sure pace. Intraoral scanners (IOSs) started to enhance the precision and trueness of the restorations, making prosthodontics treatment more predictable. The objective of this study was to compare the trueness and internal fit of the printed provisional veneers for 60 preparations with three different types of finish lines.
View Article and Find Full Text PDFBackground: In women, both earlier and later age at menarche (AAM) are associated with increased risk of coronary artery disease (CAD). This study sought to determine if the relationship of AAM with CAD and CAD risk factors differs for different underlying sources of variation in AAM - specifically, variation attributable to common genetic variants as represented by a polygenic score (PGS) vs. variation in AAM adjusted for the PGS.
View Article and Find Full Text PDFKawasaki disease (KD) is a leading cause of acquired heart disease in children, often resulting in coronary artery complications such as dilation, aneurysms, and stenosis. While intravenous immunoglobulin (IVIG) is effective in reducing immunologic inflammation, 10-15% of patients do not respond to initial therapy, and some show resistance even after two consecutive treatments. Predicting which patients will not respond to these two IVIG treatments is crucial for guiding treatment strategies and improving outcomes.
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