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Engineering synthetic vectors for improved DNA delivery: insights from intracellular pathways. | LitMetric

Engineering synthetic vectors for improved DNA delivery: insights from intracellular pathways.

Annu Rev Biomed Eng

Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA.

Published: October 2004

AI Article Synopsis

  • Significant advancements have been made in nonviral gene delivery, but synthetic vectors still lag behind viral vectors in efficiency.
  • Ongoing research focuses on overcoming obstacles related to DNA delivery through innovative designs that mimic virus-like particles.
  • There's a need for better principles and quantitative analyses to guide the rational design of these vectors, alongside a critical examination of current progress and future possibilities in the field.

Article Abstract

Significant progress has been made in the area of nonviral gene delivery to date. Yet, synthetic vectors remain less efficient by orders of magnitude than their viral counterparts. Research continues toward unraveling and overcoming various barriers to the efficient delivery of DNA, whether in plasmid form encoding a gene or as an oligonucleotide for the selective inhibition of target gene expression. Novel components for overcoming these hurdles are continually being incorporated into the design of synthetic vectors, leading to increasingly more virus-like particles. Despite these advances, general principles defining the design of synthetic vectors are yet to be developed fully. A more quantitative analysis of the cellular uptake and intracellular processing of these vectors is required for the rational manipulation of vector design. Mathematical frameworks with a more conceptual basis will help obtain an integrated perspective on these complex systems. In this review, we critically examine the progress made toward the improved design of synthetic vectors by the strategic exploitation of intracellular mechanisms and explore newer possibilities to overcome obstacles in the practical realization of this field.

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Source
http://dx.doi.org/10.1146/annurev.bioeng.6.040803.140203DOI Listing

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