AI Article Synopsis
- The study analyzed the content and dissolution rates of three compounds (theophylline, diprophylline, and proxyphylline) from a sustained release formulation using UV in situ densitometry.
- The researchers utilized high performance thin layer chromatography to separate the compounds, quantifying them with a polynomial function based on specific ng ranges for each substance.
- The method proved to be efficient, allowing for monitoring of the dissolution percentages over time, while also being simple, accurate, low-cost, and capable of processing up to 18 samples at once.
Article Abstract
The content and dissolution rate of theophylline, diprophylline and proxyphylline from a sustained release formulation were determined by UV in situ densitometry. After separation the chromatographic zones corresponding to the spots of theophylline, diprophylline and proxyphylline on the high performance thin layer chromatographic plates were scanned in reflectance/absorbance mode at 275 nm. Quantification was performed with a second degree polynomial function over the range 40-200 ng for theophylline and 60-300 ng for diprophylline and proxyphylline. Percentages of dissolved theophylline, diprophylline and proxyphylline were monitored over 1, 3 and 6 h. The method was found to be simple, accurate, reliable, time-saving (up to 18 samples can be determined simultaneously) and low-cost.
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| http://dx.doi.org/10.1002/bmc.1130060309 | DOI Listing |
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