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A CIA strategy with eminent drug-loading capacities for tumor ferroptosis-gas synergistic therapy.
Theranostics
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Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong 510515, China.
: A common challenge of drug loading and delivery using magnetic resonance imaging (MRI) contrast agents (CAs) is the tendency of aggregation and precipitation at high drug loading conditions. Herein, we propose a generic strategy of controlled ideal aggregation (CIA) to restrict the tendency. : Fe, β-Lapachone (LAP), brequinar (BQR), or Sorafenib (SOR) was respectively loaded onto Gd poly (acrylic acid) macrochelate (GP), an MRI CA, in the hollow core of nitrite-modified hollow mesoporous organosilica nanoparticles (HMON-SNO).
View Article and Find Full Text PDFPotential COX-2 inhibitors modulating NF-κB/MAPK signaling pathways: Design, synthesis and evaluation of anti-inflammatory activity of Pterostilbene-carboxylic acid derivatives with an oxime ether moiety.
Bioorg Med Chem
November 2024
Guangxi University of Chinese Medicine, Nanning 530001, China. Electronic address:
In this work, a series of novel Pterostilbene-oxime ether-carboxylic acid (POC) derivatives (d1-d10, e1-e10 and 1-13) were designed, synthesized, and characterized by spectroscopic techniques. In order to further determine the absolute configuration of these compounds, one of them, compound d3, was investigated by X-ray single crystal diffraction method. d3 had a triclinic crystal with P-1 space group, and its CHCH and CHN was confirmed as E configuration.
View Article and Find Full Text PDFTargeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies.
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Centro de Química de Coimbra, Institute of Molecular Sciences (CQC-IMS), Departamento de Química, Faculdade de Ciências e Tecnologia, University of Coimbra, 3004-535 Coimbra, Portugal.
Vascular endothelial growth factor receptor 2 (VEGFR-2) is a crucial mediator of angiogenesis, playing a pivotal role in both normal physiological processes and cancer progression. Tumors harness VEGFR-2 signaling to promote abnormal blood vessel growth, which is a key step in the metastasis process, making it a valuable target for anticancer drug development. While there are VEGFR-2 inhibitors approved for therapeutic use, they face challenges like drug resistance, off-target effects, and adverse side effects, limiting their effectiveness.
View Article and Find Full Text PDFEffects of nitrification and urease inhibitors on nitrous oxide emissions and concentrations driven by soil moisture in sandy soils.
J Environ Manage
November 2024
State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, China.
Article Synopsis
- - Soil moisture and nitrogen fertilizers influence nitrous oxide (N₂O) levels in the soil, but the effects of nitrification and urease inhibitors in different moisture conditions are not well understood.
- - A study conducted a soil column experiment using sandy soil from a cotton field to assess N₂O emissions under different fertilizer treatments and moisture levels, revealing that inhibitors reduced N₂O emissions by 33.2%-58.2% compared to urea alone.
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Therapeutic efficacy of brown propolis from Araucaria sp. in modulating rheumatoid arthritis.
Inflammopharmacology
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University of Franca, Franca, SP, 14404-600, Brazil.
Rheumatoid arthritis is a systemic inflammatory autoimmune disease with prevalence estimated at 0.5% to 1% of the population. As one of the treatment routes of rheumatoid arthritis is based on the use of nonsteroidal anti-inflammatory drugs, the use of natural products with anti-inflammatory potential becomes relevant.
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