The distribution of HCH isomers, DDT analogues and selected PCB congeners in pork organs collected from the same individuals raised in Romanian farms was investigated. Organochlorine pesticides (HCHs and DDTs) were the principal contaminants in all samples, while PCB concentrations were low, in accordance with previously reported concentrations from Romanian animal farms. The most part of the pollutant load in the body is retained in the adipose tissue, with HCHs ranging between 16 and 27.7 ng/g lipid and with higher concentrations of DDTs ranging between 65.9 and 334.5 ng/g lipid. The highest PCB levels (up to 32 ng/g lipid) were measured in lung and liver. The lipid-normalized concentrations in the brain were lower than in all other tissues due to the presence of the blood-brain barrier or due to a lower proportion of the neutral lipids such as triglycerides. The highest concentrations of DDTs were measured in muscle and fat, with p,p'-DDE being the principal contributor and with a variable contribution of p,p'-DDD and p,p'-DDT. In liver, p,p'-DDD has a higher contribution to the sum DDTs, while in all analyzed livers, the concentration of p,p'-DDT was very low. beta-HCH was the most persistent HCH isomer in all tissues, accounting for 40-97% of sum HCHs. For all animals, the highest concentrations of beta-HCH and HCHs were found in liver, while the lowest HCH concentrations were measured in brain and spinal marrow. Additionally, the distribution of alpha-HCH enantiomers in the tissues was discussed. In all samples (except 2 brain samples), (+) alpha-HCH was depleted and (-) alpha-HCH was enantioenriched. Enantiomeric ratios in brain were the highest measured values between all organs. For all studied animals, ERs increased in the order fat < muscle < liver < brain.
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http://dx.doi.org/10.1016/j.chemosphere.2004.02.014 | DOI Listing |
J Environ Sci (China)
July 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Bottom sediments of the North American Great Lakes are characterized by a high loading (over 3,000 tonnes) of polyhalogenated carbazoles (PHCZs). The origin of this environmental contaminant loading is unclear. Here, we first examined PHCZs levels and profiles in sediment, lotus, and fish from the Ya-Er Lake (China) that has been under the influence of an obsolete chlor-alkali facility for forty years and discovered substantial PHCZs contamination.
View Article and Find Full Text PDFEnviron Res
January 2025
School of Public Health, Capital Medical University, Beijing 100069, China. Electronic address:
Based on the third Chinese National Human Milk Survey (NHMS) conducted in 2016-2019, three typical legacy brominated flame retardants (BFRs), namely decabromodiphenyl ether (BDE-209), tetrabromobisphenol A (TBBPA), and hexabromocyclododecanes (HBCDDs, sum of three isomers), were measured in 100 pooled human milk samples collected from 24 provinces across China. The median concentrations of BDE-209, TBBPA and HBCDDs were 0.27, 0.
View Article and Find Full Text PDFAAPS J
January 2025
Moderna, Inc., Cambridge, Massachusetts, USA.
While the branched DNA (bDNA) assay is an established bioanalytical method for measurement of lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) pharmacokinetic parameters, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) has been considered as an alternative platform. RT-qPCR and bDNA platforms were compared for sensitivity, specificity, correlation, and overall assay performance using serum and tissue samples from 2 nonclinical mouse studies of a therapeutic mRNA candidate, LNP-PAH-mRNA, which encodes for human phenylalanine hydroxylase enzyme. Pharmacokinetic parameter noncompartmental analysis was completed using Phoenix WinNonlin.
View Article and Find Full Text PDFWater Res X
May 2025
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Emerging organophosphate flame retardants (E-OPFRs) are a new class of pollutants that have attracted increasing attention, but their bioaccumulation patterns and trophodynamic behaviors in aquatic food webs still need to be validated by comparison with legacy OPFRs (L-OPFRs). In this study, we simultaneously investigated the bioaccumulation, trophic transfer, and dietary exposure of 8 E-OPFRs and 10 L-OPFRs in a tropical estuarine food web from Hainan Island, China. Notably, the ΣL-OPFRs concentration (16.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Food Laboratory of Zhongyuan, Luohe, 462000, Henan Province, PR China.
Background: Edible oils are susceptible to contamination with polycyclic aromatic hydrocarbons (PAHs) throughout production, storage, and transportation processes due to their lipophilic nature. The necessity of quantifying PAHs present in complex oil matrices at trace levels, which bind strongly to impurities in oil matrices, poses a major challenge to the accurate quantification of these contaminants. Therefore, the development of straightforward and effective methods for the separation and enrichment of PAHs in oil samples prior to instrumental analysis is paramount to guaranteeing food safety.
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