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Placental weight as a predictor of future health: Insights from a large-scale genome-wide association study.
Placenta
March 2025
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Reproductive Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Introduction: Placental weight has been associated with various adult-onset diseases, but the causal relationships and underlying mechanisms remain unclear.
Methods: This two-sample Mendelian randomization (MR) study utilized genome-wide association study (GWAS) data from multiple independent cohorts, primarily of European ancestry. The analysis included over 1.
Tolerance to cooked egg in infants with risk factors for egg allergy after early introduction of baked egg.
Allergol Immunopathol (Madr)
March 2025
Allergology and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona.
Egg allergy (EA),along with cow's milk allergy (CMA) and atopic dermatitis (AD is one of the most frequent allergies in children. Tolerance to food allergens seems to be related to the early and regular intake and the cooking method. The objective of this study is to prove that the introduction of baked eggs at 4-6 months of age and its daily maintenance for 6 months prevents EA.
View Article and Find Full Text PDFEarly Origins of Asthma and Allergies: Clues From Studies in China.
Clin Exp Allergy
March 2025
Department of Paediatrics, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Asthma and allergies have emerged as some of the most common chronic diseases, particularly in developed countries. Epidemiological studies have consistently demonstrated that children growing up in farming/rural environments are less likely to develop these conditions. Over the past three decades, China has experienced unprecedented economic development and urbanisation, accompanied by a rapid rise in the prevalence of allergic disorders.
View Article and Find Full Text PDFInfluence of infant feeding practices on childhood dietary patterns in Upstate KIDS.
Appetite
March 2025
Epidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Dr, 20817, Bethesda, MD. Electronic address:
Background: Earlier feeding practices may influence dietary preference. We evaluated if age of introduction to select complementary foods shape intake and diet quality as measured by the Youth Healthy Eating Index (YHEI) in childhood.
Methods: Parents from the Upstate KIDS cohort reported complementary food introduction of 4-12-month-old infants on food questionnaires.
Ellagic acid ameliorates atherosclerosis by inhibiting PCSK9 through the modulation of FoxO3 and HNF1α.
Nutrition
February 2025
Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China; College of Resources, Environment, and Chemistry, Chuxiong Normal University, Chuxiong, China.
Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) hinders the clearance of low-density lipoprotein cholesterol (LDL-C) by promoting the degradation of the low-density lipoprotein receptor (LDLR), leading to the accumulation of LDL-C and thus becoming an important cause of atherosclerosis. Ellagic acid, a naturally occurring polyphenol widely present in fruits, vegetables, and nuts, has attracted significant attention due to its potential role in the prevention and treatment of cardiovascular diseases. However, the molecular mechanisms by which ellagic acid alleviates atherosclerosis by inhibiting PCSK9 are not fully understood.
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