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Predicting Heart Rate at the Anaerobic Threshold Using a Machine Learning Model Based on a Large-Scale Population Dataset.
J Clin Med
December 2024
Department of Cardiovascular Medicine, Sakakibara Heart Institute, Tokyo 183-0003, Japan.
For effective exercise prescription for patients with cardiovascular disease, it is important to determine the target heart rate at the level of the anaerobic threshold (AT-HR). The AT-HR is mainly determined by cardiopulmonary exercise testing (CPET). The aim of this study is to develop a machine learning (ML) model to predict the AT-HR solely from non-exercise clinical features.
View Article and Find Full Text PDFPericytes in Glioblastoma: Hidden Regulators of Tumor Vasculature and Therapy Resistance.
Cancers (Basel)
December 2024
Research Group on Tumors of the Central Nervous System, Pathology Department, University of Valencia, 46010 Valencia, Spain.
Glioblastoma IDH wild type (GB), the most common malignant primary brain tumor, is characterized by rapid proliferation, extensive infiltration into surrounding brain tissue, and significant resistance to current therapies. Median survival is only 15 months despite extensive clinical efforts. The tumor microenvironment (TME) in GB is highly specialized, supporting the tumor's aggressive behavior and its ability to evade conventional treatments.
View Article and Find Full Text PDFIsolation of a Novel Low-Temperature-Active and Organic-Solvent-Stable Mannanase from the Intestinal Metagenome of .
Int J Mol Sci
December 2024
Metabolic Engineering Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea.
The black soldier fly, , is a voracious scavenger of various organic materials; therefore, it could be exploited as a biological system for processing daily food waste. In order to survey novel hydrolytic enzymes, we constructed a fosmid metagenome library using unculturable intestinal microorganisms from . Through functional screening of the library on carboxymethyl cellulose plates, we identified a fosmid clone, the product of which displayed hydrolytic activity.
View Article and Find Full Text PDFHighly Stable Flexible SERS-Imprinted Membrane Based on Plasmonic MOF Material for the Selective Detection of Chrysoidin in Environmental Water.
Polymers (Basel)
December 2024
Hainan Engineering Research Center of Tropical Ocean Advanced Opto-Electrical Functional Materials, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Chrysoidin (CG) can be ingested into the human body through the skin and cause chronic toxicity, so the detection of CG levels in the environment is crucial. In this study, we synthesize F-Ag@ZIF-8/PVC molecular-imprinted membranes (FZAP-MIM) by an innovative combination of SERS detection, membrane separation, and a molecular-imprinted technique in order to perform the analysis of CG in water. The plasmonic MOF material as a SERS substrate helps to enrich the target and realize the spatial overlap of the target with the nanoparticle tip "hotspot".
View Article and Find Full Text PDFTending to the Facial Surfaces of a Mathematical Biology Head-Scratcher: Why Does the Head of the Sea Turtle Resemble a Convex Zygomorphic Dodecahedron?
Animals (Basel)
January 2025
Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA.
Two convex polyhedra that markedly resemble the head of the flatback sea turtle hatchling are identified. The first example is a zygomorphic tetragonal dodecahedron, while the other, an even better matching structure, is a related tetradecahedron, herein speculated to arise from this particular dodecahedron via known mechanisms gleaned from studies of the behavior of foams. A segmented, biomorphic, convex polyhedral model to address cephalic topology is thus presented stemming from solid geometry, anatomical observations, and a recently computed densest local packing arrangement of fifteen slightly oblate spheroids in which fourteen oblate spheroids surround a central such spheroid.
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