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Percutaneous coil embolization of a post-traumatic left anterior descending coronary artery pseudoaneurysm: a case report.
Eur Heart J Case Rep
December 2024
Division of Cardiovascular Medicine, University of Miami, Leonard M. Miller School of Medicine, 1400 NW 12th Ave, Miami, FL 33136, USA.
Background: Coronary artery pseudoaneurysm (PSA) is a rare occurrence linked to percutaneous coronary interventions (PCIs), infection, or chest trauma, lacking established management guidelines due to its low incidence.
Case Summary: A 78-year-old male with a medical history of triple vessel disease, post coronary artery bypass grafting, heart failure, and chronic obstructive pulmonary disease, presented with intractable left-sided chest pain following a mechanical fall. The initial workup was positive for mildly elevated high-sensitivity troponin and brain natriuretic peptide raising suspicion for a pulmonary embolism; but chest computed tomography angiography revealed an enlarging pericardial haematoma.
Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells.
Biochim Biophys Acta Mol Cell Res
January 2025
IRCCS Neuromed, Pozzilli, IS, Italy; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy. Electronic address:
Atrial natriuretic peptide (ANP), a cardiac hormone involved in the regulation of water/sodium balance and blood pressure, is also secreted by endothelial cells, where it exerts protective effects in response to stress. Autophagy is an intracellular self-renewal process involved in the degradation of dysfunctional cytoplasmic elements. ANP was recently reported to act as an extracellular regulator of cardiac autophagy.
View Article and Find Full Text PDFBlunted increase in plasma BNP during acute coronary syndrome attacks in obese patients.
Int J Cardiol Heart Vasc
October 2024
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine.
Background: Unexpectedly low natriuretic peptide (NP) levels in proportion to heart failure severity are often observed in obese individuals. However, the magnitude of NP elevation in response to acute cardiac stress in obesity has not yet been extensively studied. This study aimed to determine the impact of obesity on the increase in plasma NP in response to cardiac hemodynamic stress during acute coronary syndrome (ACS) attacks.
View Article and Find Full Text PDFMatairesinol blunts adverse cardiac remodeling and heart failure induced by pressure overload by regulating Prdx1 and PI3K/AKT/FOXO1 signaling.
Phytomedicine
December 2024
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, PR China; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, PR China. Electronic address:
Article Synopsis
- Pathological cardiac remodeling, a process that can lead to heart failure, involves inflammation and cell death, with Matairesinol (Mat) showing promise in counteracting these effects due to its diverse pharmacological benefits.
- The study focuses on determining if Mat can reduce cardiac hypertrophy and remodeling from pressure overload while exploring its underlying mechanisms.
- Results indicated that Mat effectively reduced cardiac hypertrophy and fibrosis, improved heart function, and lowered cell death and oxidative damage in both in vitro and in vivo models.
Molecular biomarkers of blunt cardiac injury: recent advances and future perspectives.
Expert Rev Mol Diagn
November 2024
Department of Forensic Pathology, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, Guangdong, China.
Introduction: Blunt cardiac injury (BCI), associated with high morbidity and mortality, involves multiple injuries. With no widely accepted gold standard diagnostic test and molecular biomarkers still in debate and far from application in clinical practice, exploring specific molecular biomarkers of BCI is of great significance. The clarification of molecular biomarkers can improve the diagnosis of BCI, leading to more precise care for victims in various situations.
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