AI Article Synopsis
- The study aimed to determine if the medication Ramatroban could be reduced for patients with perennial allergic rhinitis once their nasal symptoms improved.
- After administering Ramatroban for 4 weeks, significant improvements were observed in symptoms like sneezing, runny nose, and congestion, and these benefits persisted even after the dosage was halved for another 4 weeks.
- The research also showed a significant reduction in eosinophils in nasal smears, indicating decreased inflammation, supporting the idea that the medication dose can be lowered without losing effectiveness.
Article Abstract
We investigated whether or not we could reduce the medication for patients with perennial allergic rhinitis after improvement of the nasal symptoms. We administered the thromboxane A2 receptor antagonist Ramatroban, which also improves non-specific hypersensitivity, for 4 weeks and then reduced the dose to half for 4 weeks and investigated the severity of general symptoms and each nasal symptom (sneeze, rhinorrhea, and congestion). There was a significant improvement in the severity of general symptoms and each nasal symptom for the first 4 weeks (p<0.01), which was maintained for 4 weeks after reduction of the dose (n=14). There was no difference in the severity of symptoms between the reduced dosage (n=14) and the maintained dosage (n=15) groups. We also investigated the level of eosinophilia in nasal smears before and after the treatment (n=14) and showed that the level was significantly (p<0.01) reduced after the start of treatment. In conclusion, it was noted that we could reduce the dose of Ramatroban after the improvement of nasal symptoms on patients with perennial allergic rhinitis.
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