J Control Release
School of Materials Engineering, Nanyang Technological University, N4.1-1-30, Nanyang Avenue, 639798, Singapore.
Published: July 2004
We have studied the in vitro release kinetics of two important antirestenosis drugs from biodegradable stent matrices. A helical stent incorporating drugs was exposed to buffer, and both degradation-controlled and diffusion-controlled drug releases were observed. New methods for in vitro drug release for both paclitaxel and rapamycin have been developed. The release profile shows a slow diffusion-controlled phase, followed by a more rapid degradation-controlled region. In the early part of the drug release, no burst effect is observed for either drug. This might be significant for paclitaxel administration, where cardiotoxicity has been sometimes of concern. By suitable polymer/drug formulations, it is possible to develop controlled release stent matrices that can exhibit a variety of release profiles. These release profiles may have relevance to antirestenotic effects and to local or systemic toxic effects.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jconrel.2004.04.011 | DOI Listing |
Br J Surg
June 2024
Assistance Publique-Hôpitaux de Paris (APHP), University Hospitals Paris Seine-Saint-Denis, Avicenne University Hospital, Thoracic and Vascular Surgery, Sorbonne University Paris Nord, Bobigny, France.
Front Bioeng Biotechnol
May 2024
Orthopedics Department, Longgang District People's Hospital of Shenzhen and the Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, China.
Articular cartilage injuries present a significant global challenge, particularly in the aging population. These injuries not only restrict movement due to primary damage but also exacerbate elderly degenerative lesions, leading to secondary cartilage injury and osteoarthritis. Addressing osteoarthritis and cartilage damage involves overcoming several technical challenges in biological treatment.
View Article and Find Full Text PDFJTCVS Tech
October 2023
Chirurgie Thoracique et Vasculaire, Assistance Publique - Hôpitaux de Paris, Hôpitaux Universitaires Paris Seine-Saint-Denis, Hôpital Avicenne, Université Sorbonne Paris Nord, Faculté de Médecine SMBH, Bobigny, France.
JTCVS Tech
October 2023
Thoracic and Foregut Surgery, University of Minnesota, Minneapolis, Minn.
Lab Chip
March 2023
Smart Materials Group, Istituto Italiano di Tecnologia, via Morego 30, Genoa, Italy.
Biodegradable stent coatings have shown great potential in terms of delivering drugs to a damaged vessel wall, and their release profiles are key elements governing the overall performance of drug-eluting stents (DESs). However, release and degradation kinetics are usually not tested under simulated physiological conditions or in dynamic environments, both essential aspects in the design of novel DESs. To bridge this gap, fused silica-based microfluidic systems, with either round or square channel cross-sections, were designed to mimic the microenvironment of a stented vessel.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.