AI Article Synopsis
- The study aimed to evaluate how zinc oxide and eugenol impact the growth of the fungus Aspergillus fumigatus in lab settings using samples from infected sinuses.
- Zinc oxide solution was found to promote fungal growth, whereas eugenol inhibited it; however, the inhibitory effect of eugenol decreased over time, particularly after 75 days.
- The findings suggest that as eugenol concentration diminishes in endodontic sealers over time, the supportive effect of zinc oxide on fungal growth increases, leading to potential clinical issues years after dental treatment.
Article Abstract
Objective: The purpose was to show the capacity of zinc oxide and eugenol to affect the growth of Aspergillus fumigatus.
Study Design: An in vitro microbiological analysis was conducted on samples from infected maxillary sinuses and on 3 different endodontic sealers.
Results: Tests showed that zinc oxide in solution favors the growth of Aspergillus fumigatus, while eugenol inhibits this growth, even when mixed with zinc oxide powder. This inhibiting effect decreases over time. A reduced effectiveness was demonstrated over a 75-day period.
Conclusions: The hypothesis is that the diminishing concentration of eugenol over time in endodontic sealers allows the zinc oxide to support growth of Aspergillus fumigatus. This is reinforced by clinical experience, where mycetoma has developed years after endodontic therapy with excess sealer in the maxillary sinus.
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| http://dx.doi.org/10.1016/j.tripleo.2003.12.035 | DOI Listing |
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