Pulmonary aspergillosis may be classified under three main categories. These are invasive pulmonary aspergillosis, allergic bronchopulmonary aspergillosis and aspergilloma. Sometimes more than one form of the disease may be present at the same time. Semi-invasive aspergillosis is different from aspergilloma in that there is local invasion of the lung tissue. We have observed a previously healthy 42 year old female with a solitary pulmonary nodule on her radiograms. A diagnosis of endobronchial semi-invasive aspergillosis was established in this patient. We aimed to present this case report with a review of the literature.
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Controversies in the clinical management of chronic pulmonary aspergillosis.
Breathe (Sheff)
October 2024
Liverpool Hospital, Department of Respiratory and Sleep Medicine, Liverpool, Australia.
Article Synopsis
- * Treatment options for this condition include antifungal medications, minimally invasive procedures, and surgical interventions, though some patients may not be eligible for surgery due to their overall health.
- * Effective management, especially for more complicated cases, often requires a team-based approach due to the lack of extensive research and controlled studies.
[Aspergillus-related respiratory conditions and COPD: Diagnostic challenges].
Rev Mal Respir
April 2020
Service de pneumologie, université Paris Descartes, groupe hospitalier Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address:
Introduction: The relations between chronic obstructive pulmonary disease (COPD) and respiratory diseases due to Aspergillus spp. are not well understood.
Methods: We analysed a retrospective series of patients hospitalized with a diagnosis of COPD and respiratory disease due to Aspergillus.
Expanding the spectrum of chronic necrotising (semi-invasive) aspergillosis: a series of eight cases presenting as radiologically solid lung nodules mimicking malignancy.
Histopathology
April 2020
Department of Thoracic Radiology, Cleveland Clinic, Cleveland, OH, USA.
Aim: To clinicopathologically characterise a subset of aspergillosis cases characterised by radiologically solid lung nodules.
Methods And Results: We reviewed our archives for lung biopsies/resections with fungal hyphae on histology. Cases classifiable as a well-established form of aspergillosis were excluded.
Evaluation of Galactomannan Testing, the -Specific Lateral-Flow Device Test and Levels of Cytokines in Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis.
Front Microbiol
October 2018
German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel, Borstel, Germany.
Article Synopsis
- Diagnosing chronic pulmonary aspergillosis (CPA) is difficult due to vague symptoms, varying radiological results, and limited reliability of diagnostic tests.
- The study evaluated the effectiveness of galactomannan (GM) testing, a specific lateral-flow device (LFD) test, and cytokines in bronchoalveolar lavage fluid (BALF) from CPA patients, respiratory disorder patients without CPA, and healthy controls.
- Results indicated that GM testing had low sensitivity but high specificity, while sensitivity for the LFD was even lower; however, they may still be useful in identifying more severe cases of CPA.
[Investigation of Virulence Factors by "Omics" Approaches].
Med Mycol J
August 2018
Medical Mycology Research Center, Chiba University.
Aspergillus fumigatus is the predominant fungal pathogen responsible for life-threatening systemic infections in humans. Recently developed high-throughput whole genome sequencing (WGS) and RNA-Seq technologies have proven to be powerful tools for systematically investigating pathogenic organisms. In this review, we present new virulence factors obtained through our "omics" researches on A.
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