Objective: To evaluate anion and osmolal gaps as diagnostic tools in methanol poisoning.
Design And Setting: Clinical observational study.
Patients And Methods: In a recent methanol outbreak, the initial triage and treatment decisions in 28 patients were based mainly upon the values of the osmolal and anion gaps on admission. Methanol and formate levels were later compared to these gaps by linear regression analysis.
Results: The correlation between the osmolal gaps and serum methanol concentrations on admission was linear (y = 1.03x+12.71, R2 = 0.94). The anion gaps correlated well with the serum formate concentrations (y = 1.12x+13.82, R2 = 0.86). Both gaps were elevated in 24 of the 28 subjects upon admission. Three patients had an osmolal gap within the reference area (because of low serum methanol), but elevated anion gap because of formate accumulation. One patient with probable concomitant ethanol ingestion had a high osmolal gap and a normal anion gap.
Conclusion: Osmolal and anion gaps are useful in the diagnosis and triage of methanol-exposed subjects. Confounders are low serum methanol and concomitant ethanol ingestion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00134-004-2373-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Perils of Methanol Exposure: Insights into Toxicity and Clinical Management.
Toxics
December 2024
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 12371, Saudi Arabia.
Methanol is a widely used industrial and household alcohol that poses significant health risks upon exposure. Despite its extensive use, methanol poisoning remains a critical public health concern globally, often resulting from accidental or intentional ingestion and outbreaks linked to contaminated beverages. Methanol toxicity stems from its metabolic conversion to formaldehyde and formic acid, leading to severe metabolic acidosis and multiorgan damage, including profound CNS effects and visual impairments.
View Article and Find Full Text PDFAuthors reply to comment on Hayman et al. "elevated osmol gaps in patients with alcoholic ketoacidosis".
Clin Toxicol (Phila)
January 2025
Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Comment on "Elevated osmol gaps in patients with alcoholic ketoacidosis".
Clin Toxicol (Phila)
January 2025
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
The neurobiology of thirst and salt appetite.
Neuron
December 2024
Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:
Article Synopsis
- The first act of life involved capturing water within cell membranes, making fluid balance vital for survival.
- The review explores how neural mechanisms compel animals to seek and consume water and salt, detailing how the brain processes information about blood osmolality and volume to trigger thirst and salt cravings.
- It also points out gaps in current knowledge about fluid homeostasis, including the identities of sensors that detect fluid imbalances and how drinking is regulated even when there’s no physiological need, like during meals.
Seed priming with cold plasma, iron, and manganese nanoparticles modulates salinity stress in hemp (Cannabis sativa L.) by improving germination, growth, and biochemical attributes.
Environ Sci Pollut Res Int
December 2024
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Using cutting-edge technologies such as non-thermal plasma and metallic nanoparticles has shown promise in ameliorating salinity-induced stress in plants. However, there are still knowledge gaps concerning the most effective strategies for mitigating salinity stress in hemp (Cannabis sativa L.) plants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!