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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer.
MAbs
December 2024
Cancer Research Therapeutic Area, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
Article Synopsis
- Exploiting TRAILR2 activation could improve cancer treatments, but past therapies faced issues like low effectiveness and liver damage.
- The new TR2/CDH3 BAB antibody targets both CDH3 and TRAILR2, enhancing apoptosis specifically in tumor cells expressing CDH3, showcasing effectiveness in various cancers and CRISPR-engineered models.
- In pancreatic cancer, where current treatments are lacking, TR2/CDH3 BAB shows promise, especially when used with other chemotherapy drugs, indicating potential for effective cancer therapy with a good safety profile.
Neural correlates of phonetic categorization under auditory (phoneme) and visual (grapheme) modalities.
Neuroscience
January 2025
School of Communication Sciences & Disorders, University of Memphis, Memphis, TN, USA.
Article Synopsis
- The study investigates how the brain processes speech sounds and their corresponding written letters, proposing that both may use similar neural pathways despite differing senses.
- Participants showed quicker and more defined categorization of spoken sounds than written letters, suggesting a difference in how these modalities are processed.
- Key brain regions, including the left inferior frontal gyrus and auditory cortex for speech, and early visual cortices for letters, demonstrate that while auditory and visual systems operate distinctly, there is some shared processing for phonetic categorization.
NACNet: A histology context-aware transformer graph convolution network for predicting treatment response to neoadjuvant chemotherapy in Triple Negative Breast Cancer.
Comput Med Imaging Graph
December 2024
Department of Mathematics and Statistics, Georgia State University, Atlanta, 30303, GA, USA; Department of Computer Science, Georgia State University, Atlanta, 30303, GA, USA; Winship Cancer Institute, Emory University, Atlanta, 30322, GA, USA. Electronic address:
Neoadjuvant chemotherapy (NAC) response prediction for triple negative breast cancer (TNBC) patients is a challenging task clinically as it requires understanding complex histology interactions within the tumor microenvironment (TME). Digital whole slide images (WSIs) capture detailed tissue information, but their giga-pixel size necessitates computational methods based on multiple instance learning, which typically analyze small, isolated image tiles without the spatial context of the TME. To address this limitation and incorporate TME spatial histology interactions in predicting NAC response for TNBC patients, we developed a histology context-aware transformer graph convolution network (NACNet).
View Article and Find Full Text PDFA Grafting Hydrogen-bonded Organic Framework for Benchmark Selectivity of CH/CO Separation under Ambient Conditions.
Angew Chem Int Ed Engl
January 2025
Fujian Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, China.
Reticular chemistry and pore engineering have garnered significant advancements in metal-organic frameworks and covalent organic frameworks, leveraging robust metal-coordination and covalent bonds. However, these achievements remain elusive in hydrogen-bonded organic frameworks, hindered by their inherent weakness in hydrogen bonding. Herein, we strategically manipulate the porosity of hydrogen-bonded frameworks through a grafting approach, culminating in the synthesis of two isomorphic HOFs, HOF-FJU-99 and HOF-FJU-100, with distinct pore environments.
View Article and Find Full Text PDFA pan-cancer single-cell RNA-seq atlas of intratumoral B cells.
Cancer Cell
October 2024
Tumor Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK. Electronic address:
Tumor-infiltrating B cells play a significant role in tumor development, progression, and prognosis, yet a comprehensive classification system is lacking. To address this gap, we present a pan-cancer single-cell RNA sequencing (scRNA-seq) atlas of tumor-infiltrating B and plasma cells across a large sample cohort. We identify key B cell subset signatures, revealing distinct subpopulations and highlighting the heterogeneity and functional diversity of these cells in the tumor microenvironment.
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