The effect of treating hypertension in the elderly (aged 60-65 years and above), and isolated systolic hypertension in particular, has not been adequately documented. In three recent studies, however, a good effect in respect of cardiovascular end points has been observed in this group of patients. We have previously suggested pharmacological treatment of a diastolic blood pressure above 100mm Hg after three to six months' observation and non-pharmacological intervention. In a patient with essential hypertension, and with no concomitant disease, systolic blood pressure should also be taken into account, and when this exceeds (100 + age) mm Hg after the same period of observation the patient should be treated pharmacologically. If a patient shows additional indications for treatment of high blood pressure, the level for initiating treatment may be lower. As of today, diuretics and beta-blockers have proven effective in reducing cardiovascular morbidity and mortality, while data on the other antihypertensive agents are still lacking.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Rapid Screening of 60 Types of Natural Toxins in Whole Blood by UPLC-Q/Orbitrap HRMS.
Fa Yi Xue Za Zhi
December 2024
Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
Objectives: To establish a rapid screening method for 60 types of natural toxins in whole blood by ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q/Orbitrap HRMS).
Methods: The chromatographic and mass spectrometric information of 60 standard samples of natural toxins were analyzed and recorded, and a screening database was built. Whole blood was pretreated by protein precipitation method combined with ultrasonic-assisted dispersion, and then a Hypersil GOLD C column was used with 5 mmol/L ammonium formate aqueous solution (containing 0.
Using a Mobile Application Disease Self-management Program to Promote Blood Pressure Control and Quality of Life in Patients With Hypertension.
Comput Inform Nurs
March 2025
Author Affiliations: Department of Nursing, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung (Dr Chen); and School of Nursing (Drs Lu, Liu, Lee, and Wu) and International and Cross-Strait Education Center (Ms Lin), National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
The study aims to assess the effectiveness of a mobile application disease self-management program regarding blood pressure control and quality of life for patients with hypertension. A single-blind randomized controlled trial. Participants in the control group (n = 51) received routine care, whereas those in the experimental group (n = 51) participated in a home-based intervention.
View Article and Find Full Text PDFBlood pressure and the brain: the conundrum of hypertension and dementia.
Cardiovasc Res
March 2025
Stroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, Building 10, 4D37, 10 Center Drive, Bethesda, MD 20814, USA.
As the population ages, the anticipated rates of dementia worldwide are likely to increase dramatically, especially in low- and middle-income countries; thus, any opportunity to modify dementia risk is especially critical. Hypertension is one risk factor that is highly prevalent, consistently important for late-life brain health, and which could represent a target for prevention of dementia. Furthermore, hypertension is the most significant modifiable risk factor for stroke.
View Article and Find Full Text PDFPlasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease.
Nephrology (Carlton)
March 2025
Endocrine Hypertension Research Centre, The University of Queensland Frazer Institute, Greenslopes and Princess Alexandra Hospitals, Brisbane, Australia.
Aim: Using urinary extracellular vesicles (uEVs), we have demonstrated the functional 'renal-K switch' mechanism (the WNK-SPAK-NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between blood pressure and CKD has led to the hypothesis that high potassium intake may be reno-protective through the same mechanism. This study used uEVs to evaluate whether plasma potassium negatively correlates with NCC and its phosphorylation (pNCC) in patients with CKD.
View Article and Find Full Text PDFAssessing blood pressure changes and hypertension-related outcomes in patients with migraine treated with erenumab: A systematic review and meta-analysis.
Headache
March 2025
Neurology Service, Department of Clinical Medicine, Complex of the Clinical Hospital of the Federal University of Parana, Curitiba, Brazil.
Objectives/background: We aimed to systematically review and summarize evidence on the effects of erenumab on systemic blood pressure (BP) in patients with migraine (International Prospective Register of Systematic Reviews ID: CRD42024571056). US Prescribing Information for erenumab was updated to include the potential risk of hypertension, although randomized trials did not link it previously. The association of this monoclonal antibody with an elevated vascular risk remains uncertain.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!