AI Article Synopsis
- Prolactin-releasing peptide (PrRP) is a peptide that may influence eating behaviors and is found in the hypothalamus and bloodstream.
- In experiments on Zucker rats, it was discovered that obese rats had significantly lower levels of plasma PrRP compared to lean rats.
- While injecting lean rats with PrRP-13 increased their food intake, it did not have any impact on the food intake of obese rats, indicating that PrRP might not play a significant role in the overeating and obesity observed in these animals.
Article Abstract
Prolactin (PRL)-releasing peptide (PrRP) is a new peptide present in the hypothalamus and in the circulation that may be involved in the regulation of feeding behavior. In the present experiment, we measured it in a well-known model of obesity, the Zucker rat. We also measured the reactivity of this animal in terms of food intake after the intraperitoneal (I.P.) or central injection of PrRP-13, a potent PrRP agonist. Plasma PrRP levels were 35% lower in obese fa/fa than in the lean rats (p<0.005). I.P. injections of PrRP-13 (10 mg/kg) stimulated food intake in lean and had no effect in obese rats (p<0.001). Intracerebral injections of PrRP-13 had no effects in both genotypes. Altogether, these results do not support a role for PrRP in the hyperphagia and obesity syndrome of the Zucker rat.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.brainres.2004.05.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!