Fertility alpha-2-microglobulin (FAMG) was demonstrated in the human bulbourethral glands by the method of indirect immunoperoxidase staining using monoclonal antibodies against FAMG. The product of the immunohistochemical reaction was primary found in the duct cells. Weak immunopositive reaction was observed in single epitheliocytes of the secretory units. FAMG-positive granularity was typically found in the supranuclear cytoplasmic zone, that corresponds to the localization of secretory granules both in the glandulocytes and in the duct cells. These results suggest, that the bulbourethral glands are probably the additional producers of human seminal plasma FAMG.
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