AI Article Synopsis
- The study examined how severe and preconditioned hypoxia affect early gene products (c-Fos and NGFI-A) and neuronal changes in rat brain areas, specifically the hippocampus and neocortex.
- Severe hypoxia led to a decrease in c-Fos and NGFI-A protein synthesis and caused harmful neuronal alterations that reflected either necrosis or apoptosis over time.
- Preconditioning prior to hypoxia prevented these damaging effects by enhancing the expression of early gene products and significantly reducing neuronal damage.
Article Abstract
The effects of severe hypobaric hypoxia and preconditioned severe hypoxia on the expression of early genes products--proteins c-Fos and NGFI-A, and structural changes in rat hippocampal and neocortical neurons were studied using Nissl staining and immunocytochemistry. Severe hypoxia was found to induce a suppression of c-Fos and NGFI-A synthesis (at 3-24 h after exposure) and delayed (by day 3-7) destructive neuronal changes, which developed according to "light" and predominantly "dark" type, that obviously reflected necrotic or apoptotic processes, respectively. The preconditioning in the regime applied abolished these pathological changes, as expressed by stimulation of early gene products expression and marked reduction of neuronal damage following severe hypoxia.
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