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Lupus disease activity state and Foxp3 gene polymorphism.

Egypt J Immunol

January 2025

Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

The autoimmune disease systemic lupus erythematosus (SLE) is presented with many clinical symptoms. The transcription factor fork head box protein 3 (Foxp3) is expressed on regulatory T (T-reg) cells and essential for its development and function. Functional single-nucleotide polymorphisms (SNPs) in the Foxp3-3279 (rs3761548 C/A) gene influence SLE pathogenesis.

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Introduction: This study aimed to investigate the accuracy of dental model printing using 2 different layer height settings and how these settings affect the fabrication of thermoformed retainers.

Methods: Subjects were recruited from the Department of Orthodontics at Case Western Reserve University and scanned according to specific selection criteria. A total of 30 stereolithography files were produced and used as reference files.

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ECG Patterns of Occlusion Myocardial Infarction: A Narrative Review.

Ann Emerg Med

January 2025

Department of Emergency Medicine, University of Minnesota, Minneapolis, MN; Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, MN.

The traditional management of acute coronary syndrome has relied on the identification of ST-segment elevation myocardial infarction (STEMI) as a proxy of acute coronary occlusion. This conflation of STEMI with acute coronary occlusion has historically overshadowed non-ST-segment elevation myocardial infarction (NSTEMI), despite evidence suggesting 25% to 34% of NSTEMI cases may also include acute coronary occlusion. Current limitations in the STEMI/NSTEMI binary framework underscore the need for a revised approach to chest pain and acute coronary syndrome management.

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Risk and Protective Factors for the Evolution of Subthreshold Depression During Early Adolescence.

J Adolesc Health

January 2025

Laboratory of Cognitive Control and Brain Healthy, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, China; Department of Psychiatry, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Purpose: Subthreshold depression refers to a condition involving clinically significant depressive symptoms that fall short of meeting the diagnostic criteria for major depressive disorder (MDD). Identifying risk and protective factors associated with the progression of subthreshold depression in early life is essential for timely prevention. However, there is limited research on this topic among early adolescents.

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A Retrospective Cohort Study of Transgender Adolescents' Gender-Affirming Hormone Discontinuation.

J Adolesc Health

January 2025

Department of Endocrinology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Purpose: To understand the rate of, and reasons for, discontinuation of gender-affirming hormones (GAH) in transgender adolescents.

Methods: Retrospective cohort study of individuals starting GAH between January 2007 and December 2022. Individuals were included if they were diagnosed with gender dysphoria, were prescribed GAH, and took GAH continuously for a minimum of 6 months.

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