Role of humoral factors in the regulation of hemopoiesis during immobilization stress.

Bull Exp Biol Med

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

Published: March 2004

Experiments were performed on CBA/CaLac mice with hyperplasia of hemopoiesis induced by 10-h immobilization. Erythropoietic and colony-stimulating activity increased under the influence of hemopoietic growth factors and other humoral substances, which plays a major role in the increase in bone marrow cellularity during immobilization stress. Erythropoietin stimulated proliferation of erythroid colony-forming units, while granulocyte colony-stimulating factor accelerated maturation of granulocyte precursors.

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http://dx.doi.org/10.1023/b:bebm.0000031551.74274.0aDOI Listing

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