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Gabapentin impairs visual development in zebrafish via retinal apoptosis and thyroid disruption.
J Hazard Mater
January 2025
School of Environmental Science and Engineering, Nanjing Tech University, Jiangsu 211816, China; Sino-Portuguese Joint International Laboratory of Aquatic Toxicology, Nanjing Tech University, 30 South Puzhu Road, Nanjing, Jiangsu Province 211816, China. Electronic address:
Gabapentin (GBP), a pharmaceutical widely used for seizures and neuropathic pain, has emerged as a contaminant in global aquatic environments, raising concerns about its ecological impact. This study investigated the effects of environmentally relevant concentrations of GBP (0, 1, 10, 1000 μg/L) on visual development in zebrafish (Danio rerio). Behavioral assays showed that GBP exposure enhanced light sensitivity, as indicated by a significant increase in total travel distance (TTD) in all exposure groups compared to controls.
View Article and Find Full Text PDFChallenges in the Management of Severe Serotonin Syndrome: A Case Report.
Cureus
December 2024
Psychiatry and Behavioral Sciences, Kaweah Delta Health Care District, Visalia, USA.
Serotonin syndrome (SS) is a potentially life-threatening condition that can result from excessive serotonergic activity, often due to SSRIs, formally known as selective serotonin reuptake inhibitors. The syndrome and its effects are often secondary to drug-drug interactions or dose-related. This case highlights a 47-year-old female who presents with a history of major depressive disorder, generalized anxiety disorder, and severe alcohol use disorder.
View Article and Find Full Text PDFSurface active ionic liquids (SAILs), offer potential advantages for pharmaceutical applications. Given the low permeability of gabapentin, an antiepileptic drug, in the gastrointestinal tract as classified by the Biopharmaceutics Classification Systems (BCS), understanding the micellization behavior of SAILs is essential for developing effective drug delivery systems to improve gabapentin bioavailability. This study explores the micellization and thermophysical behavior of SAILs (2-hydroxyethyl)ammonium laurate [2-HEA][Lau], bis(2-hydroxyethyl)ammonium laurate [BHEA][Lau], and tris(2-hydroxyethyl)ammonium laurate [THEA][Lau] in the presence of aqueous gabapentin solution at varied temperatures through COSMO analysis, electrical conductivity and surface tension measurements.
View Article and Find Full Text PDFVulvodynia - A contemporary understanding and practical approach in primary care settings.
Malays Fam Physician
December 2024
MCGP, FRCOG, Department of Obstetrics and Gynaecology, IMU University, Clinical Campus, Jalan Rasah, Bukit Rasah, Seremban, Negeri Sembilan, Malaysia.
Vulvodynia manifests as persistent vulvar pain, affecting both sexual well-being and overall quality of life. While the precise cause remains elusive, various multifaceted predisposing and precipitating factors have been identified. Neurobiological and psychosocial elements contribute to a better understanding of the management of this complex disorder.
View Article and Find Full Text PDFAddiction to Smartphone Use in Smokers Diagnosed with Type 2 Diabetes in Jordan: Are Their Medications Involved?
Healthcare (Basel)
December 2024
Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Background/objectives: The prevalence of type 2 diabetes and smoking is increasing in developing countries and is associated with deteriorated health outcomes. Also, addiction to smartphone use is an alarming behavior that can be associated with clinical factors. This study aimed to determine the prevalence and clinical correlates of smartphone addiction in smokers with T2DM in Jordan, with a particular focus on the role of medications.
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