Polysialic acid (PSA) and human natural killer (HNK)-1 carbohydrate epitopes are expressed mainly in developing neurons but also in restricted areas, even in adulthood. In the present study, we demonstrated the expression of PSA and HNK-1 epitopes in adult primary vestibular afferent neurons. In addition, we confirmed the presence of two distinct polysialyltransferases, PST and STX, that form PSA, as well as two types of glucuronyltransferases, GlcAT-P and GlcAT-S involved in the biosynthesis of HNK-1 epitopes in the vestibular endorgans. These results combined suggest that both PSA and HNK-1 carbohydrate epitopes are synthesized and may have an important role in the adult peripheral vestibular endorgans.
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Article Synopsis
- - The study examined the link between autoimmune thyroid disorders (specifically Hashimoto thyroiditis) and vestibular dysfunction in children, comparing 36 kids with the disorder to 30 healthy controls.
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