AI Article Synopsis
- The study investigates the presence and significance of M2-muscarinic acetylcholine receptor autoantibodies (M2-AAB) in patients with dilated cardiomyopathy (DCM) compared to those with idiopathic atrial fibrillation (Af) and healthy controls.
- In DCM patients, M2-AAB were found in 40% of cases, and their presence was linked to a higher occurrence of Af, suggesting an independent predictive relationship.
- Further testing showed that M2-AAB from both DCM and Af patients could impact heart activity, leading to arrhythmias, indicating their potential role in developing Af in DCM patients.
Article Abstract
Aim: To characterise the clinical significance of M2-muscarinic acetylcholine receptor autoantibodies (M2-AAB) in patients with dilated cardiomyopathy (DCM).
Methods And Results: Sera from 104 patients with DCM, age-matched with 104 patients with idiopathic atrial fibrillation (Af) and 104 healthy control subjects, were screened for M2-AAB by enzyme-linked immunosorbent assay (ELISA). IgG purified by Protein-A column was also used as a primary antibody in ELISA. In DCM, M2-AAB were detected in 40% of patients using whole sera and in 36% of patients using purified IgG. M2-AAB were also found in several patients with idiopathic Af (23%, 23%), and these frequencies were significantly higher than those in healthy subjects (8%, 8%). Af was more common in AAB-positive than in AAB-negative patients with DCM. Multivariable analysis confirmed that M2-AAB were independent predictors of the presence of Af in such patients. We determined electrophysiological changes by adding patient purified M2-AAB to chick embryos. Purified IgG from both Af and DCM patients exhibited negative chronotropic effects and induced supraventricular arrhythmias.
Conclusion: M2-AAB may play a role in mediating the development of Af in patients with DCM.
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| http://dx.doi.org/10.1016/j.ehj.2004.05.012 | DOI Listing |
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