Objective: This study continues the psychometric evaluation of a 31-item Marijuana Screening Inventory (MSI-X) with adults referred to a substance abuse clinic, by determining MSI-X reliability, factor structure, scoring cutoff accuracy, sensitivity, and specificity with a DSM-IV-TR criterion measure.
Method: A "marijuana inventory" containing demographic, MSI-X, and DSM IV-TR diagnostic items was administered to 107 adults undergoing substance-use evaluation.
Results: The MSI-X reliability was .90 with factor analysis deriving nine factors explaining 72.2% of the variance. Varimax rotation supports retention of all 31 items on nine factor-based scales. Receiver operating characteristic analysis determined MSI-X accuracy and cutoff points in relation to four DSM IV-TR diagnostic classifications. The MSI-X obtained the highest probability (.91) for accuracy in identifying both cannabis dependence and abuse, with six the optimal cutoff for maximum sensitivity (.83) and specificity (.89). Thus, MSI-X scores of > or = 6 are considered high risk. A cutoff score of 3 was associated with (probability, .90; sensitivity, .85; specificity, .81) identifying cannabis abuse only risk, providing a 3 to 5 score in the moderate risk range.
Conclusions: Clinical sample data supports the psychometric usefulness of the MSI-X as a screening tool. Marijuana lifetime use was 90% and past-year use 48%. The MSI-X identified 43% of lifetime users and 29% of past year users with moderate to high risk marijuana patterns deserving comprehensive evaluation. More males (15.9%) than females (7.5%) obtained MSI-X high-risk scores. The MSI-X empirically derived cutoff scores are within one point of the theoretical clinical cutoffs previously reported.
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http://dx.doi.org/10.1081/ada-120037381 | DOI Listing |
Nihon Rinsho
May 2012
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Discovery of usable molecular biomarkers is the step closer to a realization of personalized therapy for patients with colorectal cancer(CRC). Herein we present an update of the most recent data on promising biological prognostic and/or predictive markers, including microsatellite instability(MSI) and KRAS/BRAF mutations. Additionally, we propose a new genetic classification for CRC based on MSI and KRAS/BRAF mutation status (a 2 x 3 matrix).
View Article and Find Full Text PDFAm J Drug Alcohol Abuse
September 2006
Graduate College of Social Work, University of Houston, Houston, Texas 77204-4013, USA.
This study evaluates the concurrent, convergent and discriminant validity between the MSI-X and five other instruments completed by 107 adults. Pearson correlation analysis with follow-up t-tests found concurrent validity between the MSI-X, Drug Abuse Screening Test (DAST-20), five Substance Abuse Subtle Screening Inventory (SASSI-3) subscales, a Diagnostic Statistical Manual (DSM) IV-TR Guided Marijuana Inventory, and two Addiction Severity Index variables. As evidence of MSI-X discriminant validity, no correlations were found with three alcohol measures.
View Article and Find Full Text PDFAm J Drug Alcohol Abuse
May 2004
University of Houston, Graduate School of Social Work, Houston, TX 77204-4013, USA.
Objective: This study continues the psychometric evaluation of a 31-item Marijuana Screening Inventory (MSI-X) with adults referred to a substance abuse clinic, by determining MSI-X reliability, factor structure, scoring cutoff accuracy, sensitivity, and specificity with a DSM-IV-TR criterion measure.
Method: A "marijuana inventory" containing demographic, MSI-X, and DSM IV-TR diagnostic items was administered to 107 adults undergoing substance-use evaluation.
Results: The MSI-X reliability was .
Am J Drug Alcohol Abuse
August 2003
Graduate School of Social Work, University of Houston, Houston, Texas 77204-4013, USA.
Objective: Marijuana use prevalence, culturally confusing messages about marijuana risks, assessment dilemmas, and current screening inadequacies justify developing a marijuana specific screening inventory for assessment purposes. This article describes the Marijuana Screening Inventory (MSI-X) and its preliminary psychometric reliability, factor analyses, and factor structure.
Method: The MSI-X was administered to a community sample of 420 Army reservists participating in substance abuse educational classes.
SAR QSAR Environ Res
October 1999
Department of Chemistry, Kent State University, Ohio 44242-0001, USA.
Quantitative structure-activity relationships (QSAR) were developed for nucleoside analogs with anti-HIV activity. These compounds were investigated to determine the correlation of structure and toxicity/activity using molecular similarity analysis and structure-activity maps. A multiple-formula approach was used to perform quantitative molecular similarity analysis (QMSA) and QSAR study.
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