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Clinical Manifestations.
Alzheimers Dement
December 2024
Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: Clinically meaningful cognitive impairment has typically been defined as a single impaired test score, but this approach is prone to false-positive errors. Examining two test scores at a lower threshold (i.e.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Boston University Alzheimer's Disease Research Center, Boston, MA, USA.
Background: Traumatic encephalopathy syndrome (TES) is the proposed clinical syndrome of chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head impacts in contact/collision sports. A core clinical feature of TES is cognitive impairment, particularly in memory and executive functions. Cognitive intraindividual variability (IIV) is the extent of variability in neuropsychological test performance (i.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Banner Sun Health Research Institute, Sun City, AZ, USA.
Background: Lewy body (LB) diseases can present with overlapping prodromal, cognitive, motor, autonomic or neuropsychiatric symptoms. Intuitively, greater symptom severity should correlate with greater pathological burden, but this has not been consistently shown. LB pathology does not translate to clinical expression in Incidental LB disease.
View Article and Find Full Text PDFPhycocyanin-based multifunctional microspheres for treatment of infected radiation-induced skin injury.
Biomaterials
December 2024
Department of Plastic Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining, 314400, China. Electronic address:
Radiation therapy is a primary modality for cancer treatment; however, it often leads to various degrees of skin injuries, ranging from mild rashes to severe ulcerations, for which no effective treatments are currently available. In this study, a multifunctional microsphere (PC@CuS-ALG) was synthesized by encapsulating phycocyanin-templated copper sulfide nanoparticles (PC@CuS) within alginate (ALG) using microfluidic technology. Phycocyanin, a natural protein derived from microalgae, shows abilities to scavenge reactive oxygen species, repair radiation-induced damage to skin cells, and ameliorate macrophage-related inflammatory responses.
View Article and Find Full Text PDFResting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes.
Front Neuroimaging
December 2024
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Article Synopsis
- The study investigates the effectiveness of resting-state functional MRI (rs-fMRI) in localizing the seizure onset zone (SOZ) in epilepsy surgery through comparison with other methods like EEG and surgical outcomes.
- Over 9,500 articles were reviewed, leading to 25 that met inclusion criteria, highlighting various comparative modalities, with rs-fMRI showing significant variability in agreement when compared to different methods.
- Results showed that surgical outcomes had better agreement with rs-fMRI than EEG and intracranial EEG, and the study provided meaningful insights into the heterogeneity of SOZ identification using rs-fMRI techniques.
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