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Insulin-Like Growth Factor-1 (IGF-1) Deficiency and Metabolic-Dysfunction-Associated Steatotic Liver Disease in a Young Patient.
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Genetics Clinic, Karaiskakio Foundation, Nicosia, CYP.
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in the Western world. MASLD-associated cirrhosis prevalence is on the rise along with the obesity and metabolic syndrome epidemic. Genetic factors are included in the multi-hit model of MASLD pathogenesis and insulin-like growth factor-1 (IGF-1) has an important role.
View Article and Find Full Text PDFSynthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments.
BMC Cancer
January 2025
Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.
Background And Aim: Zinc oxide and copper oxide nanoparticles are known for their promising biological activities. This study aims to synthesize zinc oxide nanoparticles and copper-doped zinc oxide nanoparticles to harness the combined cytotoxic and anticancer effects of them in vitro and in vivo studies.
Methods: Zinc oxide nanoparticles, both doped and undoped, were synthesized using a chemical co-precipitation method.
Copper and nickel doped carbon dots for rapid and sensitive fluorescent turn-off detection of bilirubin.
Sci Rep
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Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, India.
Carbon dots doped with metals and non-metals have gained much popularity due to the enhancement in their optical and electronic properties. In this study, polyethyleneimine-functionalized transition metal (nickel or copper) doped carbon dots (CD, NiCD and CuCD) were synthesized through hydrothermal method. The carbon dots exhibited a blue fluorescence at 470 nm when excited at 350 nm.
View Article and Find Full Text PDFProtein-Polymer Conjugates as Biocompatible and Recyclable ATRP Catalysts.
Biomacromolecules
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Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.
Atom transfer radical polymerization (ATRP) is a leading method for creating polymers with precise control over molecular weight, yet its reliance on metal catalysts limits its application in metal-sensitive and environmental contexts. Addressing these limitations, we have developed a recyclable, biocompatible, robust, and tunable ATRP catalyst composed of a protein-polymer-copper conjugate, synthesized by polymerizing an -proline-based monomer onto bovine serum albumin and complexing with Cu(II). The use of this conjugate catalyst maintains ATRP's precision while ensuring biocompatibility with both and HEK 293 cells, and its high molecular weight allows for easy recycling through dialysis.
View Article and Find Full Text PDFStable Antifouling and Antibacterial Coating Based on Assembly of Copper-Phenolic Networks.
ACS Appl Bio Mater
January 2025
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.
Biofilm formation on medical devices has become a worldwide issue arising from its resistance to bactericidal agents and presenting challenges to eradicating biofouling adhesion, especially in biological fluids. Metal-phenolic networks have been demonstrated as a versatile and efficient strategy to prevent biofilm formation by endowing medical devices with prolonged antifouling and antibacterial activities in a one-step surface modification. In this study, we report a simple and environmentally friendly method using coordination chemistry between copper ions (Cu) and dopamine-containing copolymer to fabricate metal-phenolic network-based coatings.
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