Profound myocardial hypothermia (below 17 degrees C, and more often around 12 degrees C) is imperative in myocardial protection while the aorta is cross-clamped. Based on our experience in more than 800 open-heart operations, profound myocardial hypothermia can be achieved by very efficient topical cooling despite mild systemic hypothermia (30 to 33 degrees C) and a small, single dose of crystaloid K + cardioplegia. Very efficient topical cooling is achieved by a high flow (1 to 1(1/2) L/min) of continuously cooled fluid (+ 0.5 to + 2 degrees C). The great temperature-reducing capacity of the cooling system is due to a 10 to 15 meter long metal coil tube that is immersed in an ice-salt cold bath. The water pump placed in the bath makes heat exchange even more efficient. The described method of myocardial protection with stable profound myocardial hypothermia safely prolongs the ischemic time during operation to more than 2 hours. By repositioning the coil into the warm bath (39 to 40 degrees C), the whole system can be used for topical rewarming of the heart.
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Evid Based Dent
January 2025
São Leopoldo Mandic College, Campinas, Brazil.
Objectives: The aim of this study was to review the most effective topical anesthetic methods for reducing pain/discomfort prior to dental local anesthetic needle puncture for dental procedures in children and adolescents.
Methods: A scoping review was conducted. Individual search strategies were developed for each of the bibliographic databases (Cochrane, Embase, LILACS, LIVIVO, Pubmed, Scopus, PsyINFO, Web of Science), and in the gray literature (Google Scholar, Open Gray), comprehensively, without restrictions on language, publication data, or level of socioeconomic development of the country in which the study was conducted.
Lasers Surg Med
January 2025
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Objectives: This work highlights the methods used to develop a multi-pulse 1726 nm laser system combined with bulk air-cooling for selective sebaceous gland (SG) photothermolysis using thermal imaging and software algorithms. This approach enables treating to a desired tissue temperature and depth to provide a safe, effective, reproducible, and durable treatment of acne.
Methods: We designed and built a 1726 nm laser system with a 40 W maximum power output, a highly controlled air-cooling device, and a thermal camera in the handpiece, which permits real-time temperature monitoring of the epidermis.
Int J Mol Sci
October 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Niosomes are employed for their improved physical properties and stability and as a controlled delivery system. However, their large-scale production and different preparation methods affect their physical properties. The microfluidic method represents a novel approach to the preparation of niosomes that enables precise control and decreases the preparation time and steps compared to alternative methods.
View Article and Find Full Text PDFInt J Paediatr Dent
October 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
J Heart Lung Transplant
October 2024
Latner Thoracic Research Laboratories, Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Background: Recent clinical series on donation after uncontrolled cardiovascular death (uDCD) reported successful transplantation of lungs preserved by pulmonary inflation up to 3 hours postmortem. This study aims to investigate the additive effects of in situ lowering of intrathoracic temperature and sevoflurane preconditioning on lung grafts in a porcine uDCD model.
Methods: After uDCD induction, donor pigs were allocated to one of the following groups: control-static lung inflation only (SLI); TC - SLI + continuous intrapleural topical cooling (TC); or TC+Sevo - SLI + TC + sevoflurane.
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