AI Article Synopsis
- A new series of compounds called oxamides, based on indole-2-carboxamides, has been discovered to effectively target and block NR2B selective NMDA receptors.
- Some of these compounds demonstrated strong pain-relieving effects in a mouse model, specifically in the formalin test used to measure pain response.
- The findings suggest potential for these oxamide derivatives in developing treatments for conditions involving pain management.
Article Abstract
A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.
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| http://dx.doi.org/10.1016/j.bmcl.2004.05.053 | DOI Listing |
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