The synthesis of novel aza-1,7-annulated indoles was achieved and these were converted to indolocarbazoles that proved to be potent kinase inhibitors. These compounds were also evaluated in a human colon carcinoma cell line and proved to be good antiproliferative agents.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.05.088DOI Listing

Publication Analysis

Top Keywords

novel aza-17-annulated
8
aza-17-annulated indoles
8
kinase inhibitors
8
preparation novel
4
indoles conversion
4
conversion potent
4
potent indolocarbazole
4
indolocarbazole kinase
4
inhibitors synthesis
4
synthesis novel
4

Similar Publications

Background: In forensic settings, patients with intellectual disabilities are overrepresented. A relative novel treatment approach for this population is schema therapy. The goals of schema therapy for offenders with intellectual disabilities are to reduce maladaptive emotional states and to reinforce healthy emotional states and enhancing the patient's ability to ask for help.

View Article and Find Full Text PDF

Correspondence regarding "Letter to the editor: TMS-evoked potentials provide novel neurophysiological features of Tourette syndrome".

Parkinsonism Relat Disord

January 2025

Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Ohio, United States. Electronic address:

View Article and Find Full Text PDF

ESMO Global Consortium Study on the availability, out-of-pocket costs, and accessibility of cancer medicines: 2023 update.

Ann Oncol

January 2025

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: The availability and affordability of safe, effective cancer therapies are core requirements for effective cancer control. Global disparities exist in access, however, yielding unequal cancer outcomes. The goal of this study was to provide updated data regarding the formulary availability, out-of-pocket costs, and accessibility of cancer medicines in countries across the full spectrum of economic development areas.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!