AI Article Synopsis
- HMGA2 is a key protein that influences growth and development, particularly during embryogenesis and cancer formation.
- Researchers studied two types of mice lacking HMGA2 to find out how it affects gene expression, particularly focusing on a gene called IMP2, which was found to be significantly downregulated in the HMGA2-deficient embryos.
- The study revealed that HMGA2, along with a version of it found in tumors, impacts the expression of the IMP gene family differently during embryonic development.
Article Abstract
The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.
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| http://dx.doi.org/10.1016/j.febslet.2004.05.075 | DOI Listing |
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