Urinary incontinence affects about 40 million adults in the Western world. Many mechanical, behavioral, and surgical approaches have been used for its treatment. Many of the surgical techniques are successful, but about 50% of patients need re-treatment after 5 to 7 years. Although intraurethral plug-like devices could block the leak, they create a communication between the bladder and vulva, resulting in high rates of ascending urinary infections. To prevent this communication but block the bladder outlet while allowing it to open voluntarily, a new intravesical device was designed. The device could be inserted easily into the bladder of 35 patients and activated using a remote control. The use of a completely intravesical device for the management of anatomic incontinence is a novel approach. The results obtained in pilot studies showed that the device is effective in the management of stress incontinence in patients who were failures after surgery or who refused surgery.
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http://dx.doi.org/10.1089/089277904773582778 | DOI Listing |
Diabetol Metab Syndr
January 2025
Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
Background: Of the numerous complications encountered by people with diabetes (PWD), the effect on mental health is concerning. Within mental health, diabetes distress (DD) occurs when a patient has unfavourable emotional stress while managing their condition, which can be managed by coping strategies but are less studied together in Indian settings. So, the present study aimed to determine the proportion of DD and associated factors and coping skills among the PWD.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Psychology, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, 9712TS, Groningen, The Netherlands.
Recruits are exposed to high levels of psychological and physical stress during the special forces selection period, resulting in dropout rates of up to 80%. To identify who likely drops out, we assessed a group of 249 recruits, every week of the selection program, on their self-efficacy, motivation, experienced psychological and physical stress, and recovery. Using linear regression as well as state-of-the-art machine learning techniques, we aimed to build a model that could meaningfully predict dropout while remaining interpretable.
View Article and Find Full Text PDFNat Commun
January 2025
Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory of Crop Genetic Improvement, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
During cold acclimation in high-latitude and high-altitude regions, japonica rice develops enhanced cold tolerance, but the underlying genetic basis remains unclear. Here, we identify CTB5, a homeodomain-leucine zipper (HD-Zip) transcription factor that confers cold tolerance at the booting stage in japonica rice. Four natural variations in the promoter and coding regions enhance cold response and transcriptional regulatory activity, enabling the favorable CTB5 allele to improve cold tolerance.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, Shaanxi, China. Electronic address:
This study identified the amino acid sequences of peptides generated from the enzymatic hydrolysis of goat milk proteins from two different sources and annotated their functional activities. Peptidomics and molecular docking approaches were used to investigate the antioxidant and ACE inhibitory properties of the unique peptides, revealing the molecular mechanisms underlying their bioactivity. In vitro experiments showed that the IC50 values for ACE inhibition of the four peptides (LSMTDTR, QEALELIR, NIPVGILR, and QAQNVQHY) were 2.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Sericultural Research Institute, Sichuan Academy of Agricultural Sciences, Nanchong, Sichuan, China; Institute of Special Economic Animal and Plant, Sichuan Academy of Agricultural Sciences, Nanchong, Sichuan, China. Electronic address:
Understanding the global transcriptomic and metabolic changes during mulberry growth and development is essential for the enhancing fruit quality and optimizing breeding strategies. By integrating phenotypic, metabolomic, and transcriptomic data across 18 developmental and ripening stages of Da10 mulberry fruit, a global map of gene expression and metabolic changes was generated. Analysis revealed a gradual progression of morphological, metabolic, and transcriptional changes throughout the development and ripening phases.
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