AI Article Synopsis
- DGAT is a crucial enzyme in triglyceride biosynthesis, influencing not just lipid metabolism but also overall metabolic pathways and insulin sensitivity.
- Its primary functions are well understood in adipose tissue, liver, and intestine, where it contributes to high levels of triglyceride synthesis.
- However, the role of DGAT in preventing ectopic lipotoxicity in other tissues, like muscle and pancreas, needs further investigation through specific animal studies.
Article Abstract
Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only participates in lipid metabolism but also influences metabolic pathways of other fuel molecules. Changes in the expression and/or activity levels of DGAT may lead to changes in systemic insulin sensitivity and energy homeostasis. The synthetic role of DGAT in adipose tissue, the liver, and the intestine, sites where endogenous levels of DGAT activity and TG synthesis are high, is relatively clear. Less clear is whether DGAT plays a mediating or preventive role in the development of ectopic lipotoxicity in tissues such as muscle and the pancreas, when their supply of free fatty acids (FFAs) exceeds their needs. Future studies with tissue-specific overexpression and/or knockout in these animal models would be expected to shed additional light on these issues.
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| http://dx.doi.org/10.1080/07853890410028429 | DOI Listing |
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