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Genetic Loci of the Renin-Angiotensin System and IgA Nephropathy.
Genet Test Mol Biomarkers
December 2024
Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
IgA nephropathy (IgAN) is the most common primary glomerular disease. The renin-angiotensin system (RAS) plays an important role in the development of IgAN. Polymorphisms in genetic loci coding for the RAS may be associated with IgAN progression.
View Article and Find Full Text PDFAutosomal recessive renal tubular dysgenesis: antenatal ultrasound scanning and molecular investigations.
Clin Dysmorphol
December 2024
Maternal-Fetal Medicine Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong, China.
Objective: This study aimed to elucidate the fetal ultrasound characteristics, pathology, and molecular genetic etiology of autosomal recessive tubular dysplasia.
Methods: This retrospective study examined four fetuses with autosomal recessive tubular dysplasia (ARRTD) from two pregnancies, utilizing ultrasound evaluations and fetal renal pathology. Whole-exome sequencing-copy number variation analysis was employed to identify gene mutations.
Water homeostasis gene expression in the kidney of broilers divergently selected for water conversion ratio.
Poult Sci
November 2024
Center of Excellence for Poultry Science, Division of Agriculture, University of Arkansas, Fayetteville, Arkansas, USA. Electronic address:
Divergent selection of broilers for water conversion ratio has established and high-(HWE) and low- water efficient (LWE) broiler lines. Two 2 × 2 factorial experiments were conducted to assess the gene expression profile of systems involved in renal water homeostasis. In Exp.
View Article and Find Full Text PDFMulti-omics analysis reveals the role of the autophagy-related gene AGT in chemotherapy resistance in colorectal cancer and the therapeutic potential of its inhibitors.
Discov Oncol
November 2024
Department of Gastroenterology, Anqing Municipal Hospital, 352#, Renmin Road, Anqing, 246000, Anhui, PR China.
Article Synopsis
- Autophagy plays a key role in cellular balance and drug resistance in tumors, and this study focuses on the gene Angiotensinogen (AGT) in colorectal cancer (CRC) as a potential contributor to chemotherapy resistance.
- AGT expression was found to be significantly higher in CRC tissues compared to normal tissues, with elevated levels linked to shorter recurrence-free survival and enriched autophagy pathways.
- The study utilized a range of methodologies including multi-omics analysis and functional enrichment to investigate the relationship between AGT levels, drug sensitivity, and immune infiltration in CRC.
Association between plasma angiotensinogen level and response to valsartan among sample of Iraqi hypertensive patients.
Wiad Lek
November 2024
DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS, COLLEGE OF MEDICINE, UNIVERSITY OF AL-QADISIYAH, AL-QADISIYAH, IRAQ.
Objective: Aim: The main aim of the present paper is to investigate allele frequencies of rs1799983 polymorphism eNOS genes and to determine association between rs1799983 polymorphism of eNOS gene and essential hypertension in Iraqi hypertensive patients.
Patients And Methods: Materials and Methods: Data obtained at the Al-Diwaniyah teaching hospital in Iraq by researchers from the Department of Pharmacology and Therapeutics in the College of Medicine at University of Al-Qadisiyah from July 2022 to July 2023. All participants (aged 20 to 70) had been taking valsartan 160 mg once day for essential hypertension for at least two weeks before to the study.
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