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Serine protease inhibitors in patients with chronic viral hepatitis.
J Hepatol
July 1997
Department of Medicine, University of Lund, University Hospital, Malmo, Sweden.
Background/aims: This study aimed to determine whether deficiency of the major serine protease inhibitors (alpha1-antitrypsin (AAT) or alpha1-antichymotrypsin (ACT)) is associated with increased risk for chronic hepatitis B or C virus (HBV or HCV) infection.
Methods: We studied 709 adults with chronic liver disease who had undergone liver biopsy during the 14-year period 1978-92. Anti-HCV testing was carried out with second-generation ELISA and immunoblot assays (RIBA 2).
Orthotopic liver transplantation in liver-based metabolic disorders.
Eur J Pediatr
June 1994
Department of Child Health, Variety Club Children's Hospital, Kings College Hospital, London, United Kingdom.
The efficacy of orthotopic liver transplantation (OLT) in the management of more common liver-based metabolic disorders associated with severe liver damage, alpha-1-antitrypsin deficiency (PIZZ), Wilson disease and tyrosinaemia has been demonstrated and indications defined. An early mortality in excess of 15% and finite resources limit its use. Phenotypic heterogeneity make the precise indication in other disorders less certain.
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