In respect to the differences found for vitellogenin (VTG) expression in male and immature flounder, general biological aspects and a set of chemical residues in the liver were compared between flounder from the Mersey and Dee estuaries (UK). Except for alpha-HCH, all pollutant chemicals analysed in flounder liver differed highly significantly between Mersey and Dee fish. Overall, the higher liver contaminant concentrations were found in VTG-induced Mersey flounder. The biomarkers studied were not found to indicate significant differences between Mersey and Dee fish. However, when all of the minor differences are taken into consideration, it appears that the slightly lower growth rates after age 2 in Mersey flounder, lower gonadosomatic index in both mature male and female animals, less precise seasonal patterns of condition factor (CF), hepatosomatic index and gonadosomatic index, and lower CF in immature Mersey fish may well be signs of a contaminant-affected Mersey population.
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Abnormally elevated VTG concentrations in flounder (Platichthys flesus) from the Mersey estuary (UK)--a continuing problem.
Ecotoxicol Environ Saf
July 2004
School of Biological Sciences, University of Liverpool, Jones Building, Liverpool L69 3GS, UK.
Vitellogenin (VTG) plasma concentrations were measured in flounder (Platicthys flesus L.) caught in two neighbouring UK estuaries between autumn 1997 and summer 2000. As found in previous studies, male and immature female flounder that were caught in the Mersey, but not in the Dee, had abnormally elevated concentrations of VTG in their plasma-evidence of the presence of natural and synthetic estrogens and/or xenoestrogens in the Mersey.
View Article and Find Full Text PDFGeneral condition biomarkers in relation to contaminant burden in European flounder (Platichthys flesus).
Ecotoxicol Environ Saf
July 2004
School of Biological Sciences, University of Liverpool, Jones Building, Liverpool L69 3GS, UK.
In respect to the differences found for vitellogenin (VTG) expression in male and immature flounder, general biological aspects and a set of chemical residues in the liver were compared between flounder from the Mersey and Dee estuaries (UK). Except for alpha-HCH, all pollutant chemicals analysed in flounder liver differed highly significantly between Mersey and Dee fish. Overall, the higher liver contaminant concentrations were found in VTG-induced Mersey flounder.
View Article and Find Full Text PDFA biomarker approach to endocrine disruption in flounder--estrogen receptors, hepatocyte proliferation, and sperm motility.
Ecotoxicol Environ Saf
July 2004
School of Biological Sciences, University of Liverpool, Jones Building, Liverpool L69 3GS, UK.
Three different physiological parameters were assessed to determine their potential for serving as biomarkers to predict abnormally elevated vitellogenin (VTG) production in male and immature flounder. Whereas abnormally elevated mean VTG plasma concentrations clearly distinguished the Mersey and Dee flounder studied, the results showed no significant differences in estrogen receptor binding capacity or binding affinity between the two groups. Hepatocyte proliferation was not found to be a "biomarker of effect" that could specifically be used to assess an increase in VTG-related proliferation.
View Article and Find Full Text PDFHistopathological observations on liver, kidney and gonad of plaice (Pleuronectes platessa) taken from the Mersey estuary.
Mar Environ Res
November 2002
University of Liverpool, Environmental Research and Consultancy (Centre for Marine and Coastal Studies), Birkenhead, Merseyside, UK.
The Mersey estuary is the most contaminated estuary in British waters. Detailed studies are underway on the pathology of flounder (Platichthys flesus) from the Mersey and on flounder from the nearby, but less contaminated, Dee estuary. Flounder breed offshore but spend a lot of time in the estuaries, penetrating into freshwater.
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