Misoprostol is a synthetic prostaglandin E1 used during the first trimester of pregnancy as an adjacent to RU486 for medical termination of pregnancy. We present a case of a healthy 23-year-old woman who was admitted due to misoprostol overdose, used to induce an illegal abortion. Manifestations of toxicity included abdominal pain, vomiting, diarrhea and confusion. Treatment was supportive and included gastric lavage and administration of activated charcoal. Recovery was completed within a few hours, and the patient was scheduled for a dilatation and curettage the following day.
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Deaths and Severe Adverse Events after the use of Mifepristone as an Abortifacient from September 2000 to February 2019.
Issues Law Med
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Associate Professor of Family Medicine, Liberty University College of Osteopathic Medicine.
Objectives: Primary: Analyze the Adverse Events (AEs) reported to the Food and Drug Administration (FDA) after use of mifepristone as an abortifacient. Secondary: Analyze maternal intent after ongoing pregnancy and investigate hemorrhage after mifepristone alone.
Methods: Adverse Event Reports (AERs) for mifepristone used as an abortifacient, submitted to the FDA from September 2000 to February 2019, were analyzed using the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAEv3).
Acute misoprostol toxicity during the first trimester of pregnancy.
Int J Gynaecol Obstet
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Department of Obstetrics, Gynecology and Reproductive Medicine, Hospital Center Lisbon North/Santa Maria Hospital, Lisbon, Portugal.
Maternal death related to misoprostol overdose.
Obstet Gynecol
February 2007
Department of Obstetrics, Gynecology and Reproductive Medicine, Santa Maria University Hospital, Lisbon, Portugal.
Background: Misoprostol is an important drug in obstetrics and gynecology because of its uterotonic and cervical-ripening activities. The side effects are dose-related, usually transitory, and well tolerated. The toxic dosage in humans is unknown, and there is no specific antidote.
View Article and Find Full Text PDFMisoprostol overdose during the first trimester of pregnancy.
Eur J Obstet Gynecol Reprod Biol
July 2004
Department of Obstetrics and Gynecology, Soroka University Medical Center, P.O. Box 151, Beer-Sheva, Israel.
Misoprostol is a synthetic prostaglandin E1 used during the first trimester of pregnancy as an adjacent to RU486 for medical termination of pregnancy. We present a case of a healthy 23-year-old woman who was admitted due to misoprostol overdose, used to induce an illegal abortion. Manifestations of toxicity included abdominal pain, vomiting, diarrhea and confusion.
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Cochrane Database Syst Rev
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Department of Obstetrics and Gynaecology, University of Liverpool, Liverpool, UK, L69 3BX.
Background: Misoprostol is a synthetic prostaglandin which has been used to induce labour. Oral use of the drug misoprostol may be convenient, but an overdose could cause uterine hyperstimulation and precipitate labour which may be life-threatening for both mother and fetus.
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