AI Article Synopsis
- The report discusses the oxidation of cholesterol in arterial plaques by ozone, suggesting that oxysterols are uniquely formed by this process.
- Two specific oxysterols were identified through chromatography and mass spectrometry, but conventional identification methods were not used, raising concerns about potential errors.
- The claim that ozone is the sole oxidant for producing certain compounds from cholesterol remains unproven, and a reminder is given to be cautious when considering the implications of biological ozone in comparison to historical findings about singlet oxygen.
Article Abstract
The recent account of the oxidation of tissue cholesterol by ozone created in human arterial plaques by the oxidation of water by electronically excited (singlet) dioxygen depends on the identification of the oxysterols formed and on the presumption that they are formed uniquely by ozone action. The chief oxysterols found, 3beta-hydroxy-5-oxo-5,6-secocholestan-6-al and 3beta,5-dihydroxy-5beta-B-norcholestane-6beta-carboxaldehyde, were identified as their 2,4-dinitrophenylhydrazones by chromatographic properties and a single mass spectral ion m/z 597 interpreted as [M-H](-). Conventional identification procedures for oxysterols were not conducted. Accordingly, absent other evidence, error may exist; such errors are known in the literature. Moreover, the assertion that ozone be the only oxidant that could form the 5,6-secosterol aldehyde from cholesterol is unproven. Other equally novel unproven processes can be posed. The account of biological ozone mimics prior 30-year-old reports of singlet oxygen itself in biological systems. Lest a similar history develop for biological ozone three topics of steroid oxidation are here reviewed to aid in understanding the current matter. Caution in evaluating the account of biological ozone is warranted.
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| http://dx.doi.org/10.1016/j.freeradbiomed.2004.04.024 | DOI Listing |
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