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Rapid turnover of top predators in African terrestrial faunas around the Permian-Triassic mass extinction.
Curr Biol
June 2023
Evolutionary Studies Institute, University of the Witwatersrand, Johannesburg 2050, South Africa; GENUS: DSI-NRF Centre of Excellence in Palaeosciences, Johannesburg 2050, South Africa.
Catastrophic ecosystem disruption in the late Permian period resulted in the greatest loss of biodiversity in Earth's history, the Permian-Triassic mass extinction (PTME). The dominant terrestrial vertebrates of the Permian (synapsids) suffered major losses at this time, leading to their replacement by reptiles in the Triassic. The dominant late Permian predatory synapsids, gorgonopsians, were completely extirpated by the PTME.
View Article and Find Full Text PDF["Whether the Lord putted Moscow and neighbouring cities empty?": Moscow pest of 1654].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
January 2023
The first ten years of the reign of Tsar Alexei Mikhailovich were distinguished by extreme turbulence. The unsuccessful actions of the "government" of the boyar Morozov provoked chain of city riots which reached their apogee in famous "Salt Riot" in the capital. After that, religious feuding began that in near future resulted in the Schism.
View Article and Find Full Text PDFBioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in .
Front Cell Infect Microbiol
June 2021
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Development of novel anti-tuberculosis combination regimens that increase efficacy and reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs, and enhance cure rates. Such advancements would significantly improve the global TB burden and reduce drug resistance acquisition. Bioenergetics has received considerable attention in recent years as a fertile area for anti-tuberculosis drug discovery.
View Article and Find Full Text PDFSystemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches.
Adv Drug Deliv Rev
August 2021
Department of Pharmacy and Pharmacology, University of Bath, BA2 7AY, UK.
In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform technologies has led to reflection on the true status of the field and reigning in of expectations. Oral formulations of semaglutide, octreotide, and salmon calcitonin have completed Phase III trials, with oral semaglutide being approved by the FDA in 2019.
View Article and Find Full Text PDFPurpose Of Review: Retrograde tibiopedal access and interventions have contributed to advance of endovascular techniques to treat critical limb ischemia (CLI) patients. This review encompasses the spectrum from advanced diagnostic imaging and technical therapeutic approaches for infrapopliteal occlusions, to a discussion of current standards and future directions.
Recent Findings: Contemporary studies of infrapopliteal angioplasty show suboptimal short-term and 1-year clinical outcomes.
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