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Evaluation of Microvascular Density in Glioblastomas in Relation to p53 and Ki67 Immunoexpression.
Int J Mol Sci
June 2024
Department of Anatomy and Embryology, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Târgu Mures, 540142 Târgu Mures, Romania.
Glioblastoma is the most aggressive tumor in the central nervous system, with a survival rate of less than 15 months despite multimodal therapy. Tumor recurrence frequently occurs after removal. Tumoral angiogenesis, the formation of neovessels, has a positive impact on tumor progression and invasion, although there are controversial results in the specialized literature regarding its impact on survival.
View Article and Find Full Text PDFThe specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer.
Pathol Int
July 2024
Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) is associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer.
View Article and Find Full Text PDFVascular co-option in resistance to anti-angiogenic therapy.
Front Oncol
December 2023
Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy.
Three different mechanisms of neovascularization have been described in tumor growth, including sprouting angiogenesis, intussusceptive microvascular growth and glomeruloid vascular proliferation. Tumors can also grow by means of alternative mechanisms including vascular co-option, vasculogenic mimicry, angiotropism, and recruitment of endothelial precursor cells. Vascular co-option occurs in tumors independently of sprouting angiogenesis and the non-angiogenic cancer cells are described as exploiting pre-existing vessels.
View Article and Find Full Text PDFMicrovascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer.
Sci Rep
October 2023
Centre for Cancer Biomarkers CCBIO, Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression in prostate cancer, focusing on relations to quantitative imaging parameters from anatomically matched areas obtained by preoperative mpMRI, clinico-pathological features and prognosis. Tumour slides from 67 patients (radical prostatectomies) were stained for Nestin-Ki67.
View Article and Find Full Text PDFProteomic Distributions in CD34+ Microvascular Niche Patterns of Glioblastoma.
J Histochem Cytochem
January 2022
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
The poor clinical prognosis and microvascular patterns of glioblastoma (GBM) are of serious concern to many clinicians and researchers. However, very few studies have examined the correlation between microvascular niche patterns (MVNPs) and proteomic distribution. In this study, CD34 immunofluorescence staining and matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-IMS) technology were used to investigate the protein distributions in MVNPs.
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