Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC434082 | PMC |
| http://dx.doi.org/10.1128/JVI.78.14.7843-7845.2004 | DOI Listing |
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