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ALVAD 1979: PRECEDENCE, POTENTIALS, PROSPECTS AND PROBLEMS.
Cardiovasc Dis
December 1979
Cardiovascular Surgical Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, Texas.
CLINICAL TRIALS OF THE ABDOMINAL LEFT VENTRICULAR ASSIST DEVICE (ALVAD): PROGRESS REPORT.
Cardiovasc Dis
September 1979
Cardiovascular Surgical Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, Texas.
An abdominal left ventricular assist device (ALVAD) is undergoing controlled clinical trials in our institution. The ALVAD is pneumatically-actuated, synchronously or asynchronously with an external console and is interposed between the apex of the left ventricle and the infrarenal abdominal aorta. It is an order of magnitude more effective than conventional intraaortic balloon pumping.
View Article and Find Full Text PDFSEQUENTIAL ELECTROCARDIOGRAPHIC ANALYSIS OF STONE HEART SYNDROME IN A PATIENT SUPPORTED SIX DAYS WITH AN ABDOMINAL LEFT VENTRICULAR ASSIST DEVICE (ALVAD).
Cardiovasc Dis
June 1979
Cardiovascular Surgical Research Laboratories and the Division of Cardiology, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, Texas.
A 21-year-old male patient underwent aortic and mitral valve replacement for progressive cardiac failure due to acute bacterial endocarditis. Ischemic myocardial contracture developed during attempts to restore cardiac activity following hypothermic, ischemic, cardioplegic arrest. An abdominal left ventricular assist device (ALVAD) was implanted and supported the circulation for nearly six days prior to cardiac transplantation.
View Article and Find Full Text PDFULTRASTRUCTURAL ANALYSES OF BLOOD-INTERFACING LININGS FORMED WITHIN PARTIAL ARTIFICIAL HEARTS OR ABDOMINAL LEFT VENTRICULAR ASSIST DEVICES: A QUALITATIVE SCHEME FOR HUMAN PSEUDONEOINTIMAL ACCRETION KINETICS.
Cardiovasc Dis
June 1979
Cardiovascular Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, Texas.
Following each of 21 clinical trials with the partial artificial heart or abdominal left ventricular assist device (ALVAD), we have examined the blood-interfacing human pseudoneointimal (PNI) linings formed on the fibril-flocked pumping surface by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The salient results of these ultrastructural analyses can be summarized: (1) early PNI accretion kinetics (< 24 hrs) involve plasma protein adsorption, entrapment of erythrocytes, platelets, lymphocytes, numerous neutrophils and macrophages, and the deposition of fibrin within fibril flock interstices (TEM); (2) the surface (< 24 hrs) consists of interconnected fibrin strands (SEM); (3) later PNI accretion kinetics (1-6 days) involve the formation of alternating cellular and fibrin layers (TEM); (4) the surface (1-6 days) consists of cellular aggregates (inter-membrane distances of 340 A) simulating an endothelial interface (SEM, TEM). Based on these analyses, a plausible sequence of events for human PNI accretion kinetics can be advanced, i.
View Article and Find Full Text PDFULTRASTRUCTURAL ANALYSES OF STONE HEART SYNDROME AT ONSET AND SIX DAYS LATER FOLLOWING TOTAL SUPPORT OF THE CIRCULATION WITH A PARTIAL ARTIFICIAL HEART OR LEFT VENTRICULAR ASSIST DEVICE (ALVAD).
Cardiovasc Dis
March 1979
Cardiovascular Surgical Research Laboratories of the Texas Heart Institute and the Department of Pathology, St. Luke's Episcopal Hospital, Houston, Texas.
Ischemic myocardial contracture developed in a 21-year-old man following aortic and mitral valve replacement. The patient's circulation was supported totally for 6 days with an abdominal left ventricular assist device (ALVAD). Cardiac allografting was then undertaken.
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