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Chronic intestinal spirochaetosis and Giardia lamblia infection mimicking eosinophilic enterocolitis.
Lancet Infect Dis
January 2025
Institute of Pathology, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Human intestinal spirochaetosis is caused by the colonisation of the luminal membrane of the colon and rectum by anaerobic spirochaetes belonging to the genus Brachyspira. The common method used for its diagnosis is routine haematoxylin and eosin staining of colonic and rectal biopsy samples. The clinical spectrum of human intestinal spirochaetosis is heterogeneous, ranging from asymptomatic colonisation to symptoms such as chronic mucosal diarrhoea, rectal bleeding, and abdominal pain.
View Article and Find Full Text PDFGastrointestinal in men who have sex with men: A systematic review.
Int J STD AIDS
December 2024
Sexual health & HIV, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Objective: This systematic review aimed to explore any demographic, biological and behavioural characteristics of men who have sex with men (MSM) with diarrhoeagenic .
Design/methods: We searched MEDLINE, EMBASE, and CINAHL for manuscripts published to March 2024. One author screened manuscript abstracts; two authors independently conducted a full text review.
Coexistence of Intestinal Spirochetosis and Colorectal Cancer: Could the Coil be Carcinogenic?
ACG Case Rep J
November 2024
Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, North Florida/South Georgia Veterans Health System, Gainesville, FL.
Intestinal spirochetosis (IS) is an infectious gastrointestinal disease caused by bacteria. We detail an exceedingly rare case of IS with concomitant invasive colorectal adenocarcinoma (CRC) in a 58-year-old man presenting with abdominal discomfort and fever. Colonoscopic evaluation revealed abnormal-appearing, nodular cecal mucosa and a 35 mm rectosigmoid mass.
View Article and Find Full Text PDFBPP43_05035 is a cell surface adhesin that weakens the integrity of the epithelial barrier during infection.
Gut Microbes
September 2024
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
The anaerobic spirochete causes intestinal spirochetosis, characterized by the intimate attachment of bacterial cells to the colonic mucosa, potentially leading to symptoms such as diarrhea, abdominal pain, and weight loss. Despite the clinical significance of infections, the mechanism of the interaction between and the colon epithelium is not known. We characterized the molecular mechanism of the -epithelium interaction and its impact on the epithelial barrier during infection.
View Article and Find Full Text PDFGut microbiota-derived butyrate improved acute leptospirosis in hamster promoting macrophage ROS mediated by HDAC3 inhibition.
mBio
October 2024
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Article Synopsis
- Leptospirosis is a re-emerging zoonotic disease that affects both humans and animals, often causing intestinal symptoms and highlighting the importance of gut microbiota in immune response and disease resistance.
- Research indicates that short-chain fatty acids (SCFAs), particularly butyrate, play a protective role against leptospirosis by enhancing immune responses through increased reactive oxygen species (ROS) production.
- The study presents a potential therapeutic pathway through the butyrate-MCT-HDAC3i-ROS signaling axis, suggesting this could be a target for developing strategies to prevent acute leptospirosis.
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