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Real-World Experience of Immune-Checkpoint Inhibitors in Older Patients with Advanced Cutaneous Squamous Cell Carcinoma.
Drugs Aging
March 2024
Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Background: Older patients are often underrepresented in clinical trials owing to exclusionary comorbidities, which are more common with age. Chemotherapy is poorly tolerated in older comorbid advanced cutaneous squamous cell carcinoma (CSCC) patients; however, little is known on the efficacy and tolerability of immune-checkpoint inhibitors (ICIs) in this population. To our knowledge, this is the largest dedicated report on a cohort of older patients with advanced CSCC treated with immunotherapy to date.
View Article and Find Full Text PDFSurvivorship Care for Women Living With Ovarian Cancer: Protocol for a Randomized Controlled Trial.
JMIR Res Protoc
February 2024
Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center, Houston, TX, United States.
Background: Ovarian cancer ranks 12th in cancer incidence among women in the United States and 5th among causes of cancer-related death. The typical treatment of ovarian cancer focuses on disease management, with little attention given to the survivorship needs of the patient. Qualitative work alludes to a gap in survivorship care; yet, evidence is lacking to support the delivery of survivorship care for individuals living with ovarian cancer.
View Article and Find Full Text PDFPostmortem biochemistry in deaths from ischemic heart disease.
J Forensic Leg Med
November 2023
Department of Forensic Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey. Electronic address:
Ischemic heart disease (IHD) is one of the leading causes of morbidity and sudden cardiac death worldwide and is an important public health problem. The presence of ischemia in clinical applications can be detected by ECG, biochemical markers, and radiological methods. Myocardial infarction is also frequently encountered in forensic autopsies.
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