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Cardiac safety of antipsychotic medications in pediatric and adolescent population: a systematic review and pathways for future research.
Eur J Pediatr
November 2024
Child and Adolescent Psychiatry Unit, Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS 50139, Florence, Italy.
Article Synopsis
- A systematic review analyzed 10 studies involving 523 patients to evaluate how various antipsychotic medications impact the QTc interval in youngsters.
- Results indicated that risperidone and aripiprazole had minimal QTc effects, while other drugs like quetiapine and pimozide showed varying levels of prolongation, highlighting a need for more research and careful monitoring when prescribing these medications.
An Updated Safety Review of the Relationship Between Atypical Antipsychotic Drugs, the QTc Interval and Torsades de Pointe As: Implications for Clinical Use.
Expert Opin Drug Saf
September 2024
Westchester Medical Center, New York Medical College, Departments of Cardiology and Medicine, Valhalla, NY, USA.
Introduction: The rising prevalence of psychiatric disorders has resulted in a significant increase in the use of antipsychotic medications. These agents may prolong the corrected QT interval (QTc), running the risk of precipitating ventricular arrhythmias, notably Torsades de Pointes (TdP). Current recommendations vary regarding the optimal approach to safe prescribing practices and QTc surveillance for antipsychotics.
View Article and Find Full Text PDFComparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis.
Lancet Child Adolesc Health
July 2024
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Psychiatric Imaging Group, Medical Research Council London Institute of Medical Sciences, Imperial College London, London, UK.
Background: The degree of physiological responses to individual antipsychotic drugs is unclear in children and adolescents. With network meta-analysis, we aimed to investigate the effects of various antipsychotic medications on physiological variables in children and adolescents with neuropsychiatric and neurodevelopmental conditions.
Methods: For this network meta-analysis, we searched Medline, EMBASE, PsycINFO, Web of Science, and Scopus from database inception until Dec 22, 2023, and included randomised controlled trials comparing antipsychotics with placebo in children or adolescents younger than 18 years with any neuropsychiatric and neurodevelopmental condition.
Evaluation of Anti-Agitation Medication Prescribing Patterns by Age in the Emergency Department.
Fed Pract
April 2024
Veterans Affairs Southern Nevada Healthcare System, North Las Vegas.
Background: Acute agitation frequently occurs in the emergency department. Appropriate management is critical for the safety of all parties involved. Benzodiazepines and antipsychotics are commonly used for agitation, but safety concerns exist with these medications in older adults, even with acute use.
View Article and Find Full Text PDFClearing the Fog: A Review of Antipsychotics for Parkinson's-Related Hallucinations: A Focus on Pimavanserin, Quetiapine and Clozapine.
J Integr Neurosci
April 2024
Department of Medical Laboratory Sciences, College of Health Sciences, and Research Institute for Medical and Health Sciences, University of Sharjah, 27272 Sharjah, United Arab Emirates.
Parkinson's disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, including hallucinations. The use of antipsychotic medications is a common strategy to manage hallucinations associated with Parkinson's disease psychosis (PDP). However, careful consideration is necessary when selecting the most appropriate drug due to the potential risks associated with the available treatment options.
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