Corinfar-Retard efficacy in patients with hypertonic-hyperkinetic type of biliary dyskinesia has been studied. 56 patients aged 26 to 30 had been prescribed Corinfar-Retard in 20 mg per day for 7 days. Dynamic echocholecystography has applied. Decrease in contraction of gall bladder and normalization of tonic contraction of sphincter Ody was found in the patients with previously diagnosed hypertonic-hyperkinetic type of biliary dyskinesia after having been treated with Corinfar-Retard.
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In 40% cases pain and dyspepsia do not disappear after cholecystectomy made by laparotomic or laparoscopic method. The aim of the study was to introduce a new method of ultrasonic diagnosis of biliary excretion and to formulate principles of postcholecystectomy syndrome treatment depending on the dyskinesia form. The new method diagnosed 6 variants of biliary excretion: normal (7.
View Article and Find Full Text PDFCorinfar-Retard efficacy in patients with hypertonic-hyperkinetic type of biliary dyskinesia has been studied. 56 patients aged 26 to 30 had been prescribed Corinfar-Retard in 20 mg per day for 7 days. Dynamic echocholecystography has applied.
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View Article and Find Full Text PDFClinical and manometric effects of L-arginine in patients with chest pain and oesophageal motor disorders.
Ital J Gastroenterol Hepatol
August 1997
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
Background/aims: Nitroderivatives are therapeutically effective in spastic disorders of the oesophagus through the generation of nitric oxide, a non-adrenergic non-cholinergic inhibitory neurotransmitter, but their use is limited by undesirable side effects and rapid appearance of drug tolerance. As nitric oxide "in vivo" is generated from L-arginine, an amino acid normally present in the diet and completely devoid of toxic effects, we administered the latter substance in patients with chest pain and oesophageal motor disorders of the spastic type to investigate if it is able to produce clinical and manometric effects similar to those manifested by nitroderivatives.
Methods: In eight patients affected by non cardiac chest pain and oesophageal motor disorders of a hypertonic-hyperkinetic type without pathologic gastro-oesophageal reflux, a solution containing L-arginine and a placebo solution were infused in random order and double blind manner during a manometric examination of the oesophagus, taking into account the spontaneous variations of oesophageal motility connected with the phases of the Migrating Motor Complex.
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