In 1999, a Danish expert report strongly recommended the Assertive Community Treatment (ACT) model to be implemented in Denmark. On 1 May 2001 we started in the Tønder region (45,000 inhabitants), Sønderjylland (SJ) county (254,000 inhabitants), aiming an evaluation of the ACT model. Before starting the clinical study, an epidemiological baseline evaluation of trends in psychiatric service was performed. Data included all admissions to mental hospitals/wards from 1981 to 2000 from the intervention/control region (Tønder/Aabenraa) and from all Denmark together with outpatient data from the period 1995-2000. The bed rate in the SJ county (76/100,000 31 December 2000) was halved during the period. The staff increased by more than 50%. The increase in admission rate and decrease in bed days per admission showed homogeneous pattern between intervention and control region. The hospital incidence of schizophrenia and the first-time admission rate were at the same level in the intervention/control region and all Denmark, but the country had a higher use of beds. The point prevalence and referral rates of outpatients increased to around 6/1000 and 7/1000/year, respectively in both regions. In conclusion, the regions of intervention and control had, prior to the start of ACT, the same pattern of use of psychiatric services, enabling an unbiased register-based evaluation of effects.
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http://dx.doi.org/10.1080/08039480410005567 | DOI Listing |
Curr Stem Cell Res Ther
January 2025
Department of Immunology, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Since there is currently no cure for amyotrophic lateral sclerosis (ALS), it is essential to search for diagnostic biomarkers and novel treatments to reduce the severity of this disease. One of these treatment approaches is stem cell transplantation.
Objective: This study aims to evaluate the safety and efficacy of repeated transplantation of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with ALS by analyzing clinical and molecular data.
Cureus
December 2024
Ophthalmology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, TUR.
Purpose This study evaluated the efficacy of oral melatonin therapy for visual acuity and retinal and choroidal structures in patients with chronic central serous chorioretinopathy (CSCR). Methods Fourteen patients with CSCR were included; eight received oral melatonin (3 mg nightly), and six formed the control group. Best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), and choroidal vascularity index (CVI) were assessed at baseline and after one month.
View Article and Find Full Text PDFCureus
December 2024
Community Medicine/Preventive Dentistry, Dental Public Health Center, Kurdistan Higher Council of Medical Specialties, Erbil, IRQ.
Aim: This study aimed to evaluate the impact of using melatonin and vitamin C as adjuncts to the non-surgical treatment of chronic periodontitis.
Materials And Methods: This triple-blind randomized clinical trial involved 100 participants with chronic periodontitis. Subjects were randomly assigned to three groups: (1) non-surgical periodontal therapy (NSPT) alone (n = 33); (2) NSPT with melatonin (n = 33); and (3) NSPT with melatonin and vitamin C (n = 34).
Tex Heart Inst J
January 2025
Center for Women's Heart and Vascular Health, The Texas Heart Institute, Houston, Texas.
Myocardial bridging is a frequent anomaly of the heart in humans and other animals. A myocardial bridge is typically characterized by the systolic narrowing seen with traditional catheter angiography, but this abnormality is not by itself a sign of ischemia or the need for intervention. In particular, transient spontaneous angina must be corroborated by reproducible narrowing during acetylcholine testing; this narrowing occurs during resting conditions and is responsive to nitroglycerin administration.
View Article and Find Full Text PDFCan J Pain
January 2025
Bruyère Research Institute, Ottawa, Ontario, Canada.
Background: Health care providers often struggle to treat patients with chronic pain. One potential solution is to facilitate access to programs and tools that develop patients' skills and confidence in managing their own care.
Aims: This study aimed to describe the uptake of the Chronic Pain Self-Management Program (CPSMP) in Eastern Ontario and evaluate the effectiveness of the program in the acquisition of knowledge, confidence, and skills required to manage chronic pain, as measured by the Patient Activation Measure (PAM).
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