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Safety and Efficacy of Deutetrabenazine at High versus Lower Daily Dosages in the ARC-HD Study to Treat Chorea in Huntington Disease.
CNS Drugs
February 2025
Innovative Medicines and Global Clinical Development, Teva Branded Pharmaceutical Products R&D, Inc., West Chester, PA, USA.
Background: Huntington disease (HD) is a progressive neurodegenerative disease that causes psychiatric and neurological symptoms, including involuntary and irregular muscle movements (chorea). Chorea can disrupt activities of daily living, pose safety issues, and may lead to social withdrawal. The vesicular monoamine transporter 2 inhibitors tetrabenazine, deutetrabenazine, and valbenazine are approved treatments that can reduce chorea.
View Article and Find Full Text PDFLevothyroxine attenuates behavioral impairment and improves oxidative stress and histological alteration 3-nitropropionic acid induced experimental Huntington's disease in rats.
Behav Brain Res
March 2024
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Huntington's disease (HD) is a neurodegenerative disorder characterized by degeneration of the striatum; it results in oxidative stress and motor deficits. Thyroid hormones regulate oxidative metabolism. In the present study, we evaluated the effect of administration of levothyroxine (LT-4) on neurobehavioral, oxidative stress, and histological changes in a rat model of HD.
View Article and Find Full Text PDFPhenotypic features of epilepsy due to sodium channelopathies - A single center experience from India.
J Neurosci Rural Pract
October 2023
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Article Synopsis
- Approximately 40% of pediatric epilepsies are genetic, with sodium channel mutations being a common cause, particularly noted in the SCN1A gene, which is associated with various epilepsy types.
- This study analyzed 23 children with sodium channel mutations attending a center in Southern India, documenting their clinical signs, EEG results, and treatment impacts.
- The most frequent seizure type was focal with impaired awareness, and associated non-epileptic features included microcephaly and movement disorders, highlighting the need for personalized management in affected patients.
Unmasking Uremic Encephalopathy: Choreoathetoid Movements Mimicking Alcohol Withdrawal in a Person with an Alcohol Use Disorder.
Cureus
October 2023
Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, IND.
Chorea is a disorder characterized by irregular, involuntary movements affecting the limbs, trunk, neck, or face. It can be a significant symptom in various neurologic diseases, including metabolic, autoimmune, and neurodegenerative conditions. The neural foundation that underlies the genesis of chorea appears to be fairly diverse, even though its pathophysiology is frequently associated with the malfunctioning of inhibitory circuits within the basal ganglia.
View Article and Find Full Text PDFPostanoxia-Induced Chorea Treated with Intravenous Fentanyl.
Case Rep Neurol Med
April 2023
Department Chair of Neurocritical Care and ICU-EEG, Sanford USD Medical Center, Sioux Falls, South Dakota, USA.
The case presented is that of a young male with postanoxic brain injury secondary to cocaine overdose who began to exhibit choreiform movements of the left upper extremity. Traditional treatment options for chorea were unsuccessful, leading to the administration of fentanyl, which rapidly resolved the patient's choreiform movements. There is a limited research involving the treatment of chorea in anoxic brain injury as well as fentanyl's role in the movement pathway.
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