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Liver Organoids From Hepatocytes of Healthy Humans and Non-alcoholic Fatty Liver Disease (NAFLD) Patients Display Multilineage Architecture and can be Used to Develop an Model of Steatohepatitis.
J Clin Exp Hepatol
December 2024
BRIC-Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Background/aim: Non-alcoholic fatty liver disease (NAFLD) is a global health concern with limited treatment options. The paucity of predictive models in preclinical settings seems to be one of the limitations of identifying effective medicines. We therefore aimed to develop an model that can display the key hallmarks of NAFLD, such as steatosis, inflammation, and fibrosis.
View Article and Find Full Text PDFA qualitative study exploring experiences of treatment in paediatric rheumatology - children's, young people's, parents' and carers' perspectives.
Pediatr Rheumatol Online J
January 2025
School of Pharmacy, Faculty of Medical Sciences, Newcastle University, King George VI Building, Queen Victoria Road, Newcastle-upon-Tyne, NE2 4RU, UK.
Background: There is limited literature in paediatric rheumatology describing holistic lived experiences of medical treatment from perspectives of children and young people (CYP) and their parents or carers (PC). This is important as it could have implications for adherence. This study aimed to explore treatment experiences of CYP and PC in a paediatric rheumatology service.
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- The study investigates the role of ultrasound-guided fine-needle aspiration biopsy (FNAB) in diagnosing thyroid nodules larger than 3 cm, emphasizing its significance for treatment decisions.* -
- Researchers reviewed patient records from 2018 to 2023, focusing on those who underwent thyroid surgery, categorizing them by nodule size to analyze FNAB outcomes.* -
- Results indicated that larger nodules (≥4 cm) had a higher rate of malignancy and more false negatives in FNAB, stressing the need for careful evaluation in surgical planning.*
A cadaveric analysis of the efficacy of blind injections into the lateral pterygoid muscle.
Folia Morphol (Warsz)
December 2024
Discipline of Anatomy, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Article Synopsis
- Temporomandibular disorders (TMD) are a leading cause of orofacial pain, with hyperactivity of the lateral pterygoid muscle (LPM) often implicated; botulinum toxin A (BTX) injections into this muscle can be a treatment but lack standardization.
- A study conducted on five cadavers using extraoral landmark-based LPM BTX injections revealed a 0% accuracy rate and significant neurovascular disruption in 40% of cases.
- The findings underline the dangers of blind BTX injections for TMD and emphasize the need for improved treatment protocols, including the use of guided imaging techniques.
Acupuncture, an increasingly popular alternative medical therapy, has heightened the demand for information on its safety profile. This is a case report involving a 28-year-old female who presented with intense right-sided chest pain and breathlessness after an acupuncture session where needles were inserted into her chest wall. The immediate medical evaluation revealed a tension pneumothorax with radiographic evidence of a mediastinal shift, compelling, urgent intervention via chest tube insertion.
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