An outbreak of multidrug-resistant Salmonella enterica serotype Typhimurium infections occurred in Pennsylvania and New Jersey. A case-control study implicated pasteurized milk from a dairy, and an inspection indicated the potential for contamination after pasteurization. Dairy cattle are the likely reservoir, and milk may be an important vehicle of Salmonella transmission to humans.
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http://dx.doi.org/10.3201/eid1005.030484 | DOI Listing |
Front Microbiol
December 2024
Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, United States.
Introduction: Healthcare-associated infections (HAIs) pose a significant challenge in acute care hospitals, particularly in intensive care units, due to persistent environmental contamination despite existing disinfection protocols and manual cleaning methods. Current disinfection methods are labor-intensive and often ineffective against multidrug-resistant (MDR) pathogens, highlighting the need for new, automated, hands-free approaches.
Methods: This study evaluates the bactericidal efficacy of low concentrations of gaseous ozone (5 ppm) against clinically relevant and often MDR bacteria under various concentrations, contact times, temperatures, and environmental conditions.
BMC Microbiol
December 2024
Veterinary Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.
Background: Salmonella enterica is a major cause of foodborne illness and mortality worldwide, but its presence in milk along the milk supply chain and associated public health risks are under-studied. This research was aimed to investigate the occurrence and antimicrobial susceptibility of Salmonella enterica in milk, milking environments, milkers' hands, and diarrheic patients in Wolaita Sodo, Ethiopia.
Methods: We collected 644 samples from 106 dairy farms that include direct milk from cow, bulk tank milk, milkers' hand swabs, teat surfaces swabs, farm floors swabs, milk storage containers swabs, collectors' bulk milk, retailers' bulk milk, and stool from diarrheic patients.
Mol Biotechnol
December 2024
Department of Biotechnology, University of Mianwali, Punjab, 42200, Pakistan.
In Salmonella Typhimurium, efflux pump proteins, such as AcrD actively expel drugs and hazardous chemicals from bacterial cells, resulting in treatment failure and the emergence of antibiotic-resistant variants. Focusing on AcrD may lead to the development of novel antimicrobials against multidrug-resistant bacteria. However, challenges persist in achieving high selectivity, low toxicity, and effective bacterial penetration.
View Article and Find Full Text PDFJ Agric Food Chem
December 2024
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics, Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, PR China.
The wide dissemination of multidrug-resistant (MDR) Gram-negative bacteria poses a significant global health and security concern. As developing new antibiotics is generally costly, fastidious, and time-consuming, there is an urgent need for alternative therapeutic strategies to address the gap in antibiotic discovery void. This study aimed to investigate the activity of colistin (CS) in combination with a natural product, rutin (RT), to combat against Typhimurium ( Tm) in vitro and in vivo.
View Article and Find Full Text PDFJ Zoo Wildl Med
December 2024
Hospital de Especies Menores y Silvestres, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, 40104, Costa Rica.
spp. are one of the leading causes of illness, and in the last years there is an increasing interest in the role of different wild animals as reservoir of , especially multidrug resistant strains. To establish preventive and action strategies, it is essential to monitor bacterial resistance profiles and systematically collect information.
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